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经尿道膀胱肿瘤电切术对膀胱癌患者血清TNF-α、APN及VEGF水平的影响 认领

Effect of transurethral resection of bladder tumor on the levels of serum TNF-α,APN and VEGF in patients with bladder cancer
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摘要 目的分析经尿道膀胱肿瘤电切术(TURBT)对膀胱癌患者血清肿瘤坏死因子-α(TNF-α)、脂联素(APN)及血管内皮生长因子(VEGF)水平的影响。方法选择本院2017年5月至2019年5月收治的110例膀胱癌患者,将其随机分为参照组和试验组,各55例。参照组给予传统开放性膀胱部分切除术治疗,试验组给予TURBT术治疗,比较两组的治疗效果。结果试验组的术中出血量少于参照组,手术时间、留置导尿管时间及住院时间均显著短于参照组(P<0.05)。术后3 d,试验组的血清TNF-α、VEGF水平均显著低于参照组,血清APN水平显著高于参照组(P<0.05)。试验组的并发症总发生率显著低于参照组(P<0.05)。结论TURBT术可有效缩短膀胱癌的治疗时间,减轻炎症反应,抑制肿瘤标志物VEGF高表达,降低并发症发生率。 Objective To analyze the effect of transurethral resection of bladder tumor(TURBT)on the levels of serum tumor necrosis factor-α(TNF-α),adiponectin(APN)and vascular endothelial growth factor(VEGF)in patients with bladder cancer.Methods A total of 110 cases of bladder cancer patients admitted in our hospital from May 2017 to May 2019 were selected and randomly divided into reference group and test group,with 55 cases in each group.The reference group was treated with traditional open partial cystectomy,and the test group was treated with TURBT.The therapeutic effects of the two groups were compared.Results The amount of intraoperative blood loss in the test group was less than that in the reference group,and the operation time,indwelling catheter time and hospital stay were significantly shorter than those in the reference group(P<0.05).On the 3 d after operation,the serum TNF-αand VEGF levels in the test group were significantly lower than those in the reference group,and the serum APN level was significantly higher than that in the reference group(P<0.05).The total incidence of complications in the test group was significantly lower than that in the reference group(P<0.05).Conclusion TURBT surgery can effectively shorten the treatment time of bladder cancer,alleviate inflammation response,inhibit the high expression of tumor marker VEGF,and reduce the incidence of complications.
作者 张强 赵安华 谭旻喆 ZHANG Qiang;ZHAO Anhua;TAN Minzhe(the First People's Hospital of Hanbin District,Ankang 725000,China)
出处 《临床医学研究与实践》 2021年第3期84-86,共3页 Clinical Research and Practice
关键词 经尿道膀胱肿瘤电切术 膀胱癌 炎症反应 transurethral resection of bladder tumor bladder cancer inflammatory response
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