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阿司匹林联合拉贝洛尔对妊娠期高血压患者妊娠结局及血清ET-1、TSP-1水平的影响 认领

Effect of Aspirin Combined with Labetalol on Pregnancy Outcome and Serum Levels of ET-1 and TSP-1 in Patients with Gestational Hypertension
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摘要 目的探讨阿司匹林联合拉贝洛尔对妊娠期高血压患者妊娠结局及血清内皮素-1(ET-1)、血小板反应蛋白-1(TSP-1)水平的影响。方法选取我院于2018年6月至2020年3月期间收治的96例妊娠期高血压患者。按照随机数字表法分为观察组(阿司匹林联合拉贝洛尔治疗)、对照组(拉贝洛尔治疗),各48例。对比两组疗效、妊娠结局及不良反应,对比两组治疗前、治疗7 d后的血压、血清ET-1、TSP-1水平。结果观察组的临床总有效率93.75%,高于对照组72.92%(P<0.05)。治疗7 d后,两组收缩压、舒张压较治疗前下降,且观察组较对照组低(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。治疗7 d后,两组血清ET-1、TSP-1较治疗前下降,且观察组低于对照组(P<0.05)。两组产后出血、胎盘早剥、剖宫产、新生儿窒息的总发生率对比无统计学差异(P>0.05)。结论妊娠期高血压患者采用阿司匹林联合拉贝洛尔治疗,可有效控制血压,安全有效,其作用机制可能与调节血清ET-1、TSP-1水平有关。 Objective To investigate the effect of aspirin combined with labetalol on the pregnancy outcome and serum levels of endothelin-1(ET-1)and thrombospondin-1(TSP-1)in the patients with gestational hypertension.Methods 96 patients with gestational hypertension admitted into our hospital from June 2018 to March 2020 were selected and randomly divided into observation group(with treatment of aspirin combined with labetalol)and control group(with treatment of labetalol),with 48 cases in each group.The efficacy,pregnancy outcome and adverse reactions of the two groups were compared.The blood pressure and serum levels of ET-1 and TSP-1 before and 7 d after treatment were compared between the two groups.Results The total clinical effective rate of the observation group was 93.75%,higher than that of the control group which was 72.92%(P<0.05).After 7 days’treatment,the systolic blood pressure and diastolic blood pressure of the two groups decreased compared with those before treatment,and the two indexes of the observation group were lower than those of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 7 days’treatment,the serum ET-1 and TSP-1 of the two groups decreased compared with those before treatment,and the two indexes of the observation group were lower than those of the control group(P<0.05).There was no statistically significant difference in the total incidence of postpartum hemorrhage,placental abruption,cesarean section and neonatal asphyxia between the two groups(P>0.05).Conclusion The treatment of aspirin combined with labetalol for the patients with gestational hypertension can effectively control blood pressure which is safe and effective.Its mechanism may be related to the regulation of serum levels of ET-1 and TSP-1.
作者 郭丽敏 柳月霞 刘小丽 Guo Limin;Liu Yuexia;Liu Xiaoli(Department of Obstetrics,Nanyang Second General Hospital,Nanyang 473000 China)
出处 《锦州医科大学学报》 2021年第1期54-57,共4页 Journal of Jinzhou Medical University
基金 2016年河南省医学科技攻关计划项目,项目编号:201603173。
关键词 阿司匹林 拉贝洛尔 妊娠期高血压 妊娠结局 内皮素-1 血小板反应蛋白-1 aspirin labetalol gestational hypertension pregnancy outcome endothelin-1 thrombospondin-1
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