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miR-802和RAB23在前列腺癌中的表达水平及与临床病理特征和预后的相关性 认领

The expression level of miR-802 and RAB23 in prostate cancer and their relationships with clinicopathological features and prognosis
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摘要 目的:检测前列腺癌患者肿瘤组织中微小RNA(miRNA)及RAB23表达水平,分析其与临床病理特征及预后的关系。方法:选取2011年2月至2014年2月本院确诊并进行前列腺根治手术治疗的前列腺癌患者150例为研究对象,选择同期因良性前列腺增生行电切手术的患者150例为对照组,利用免疫组化法(SP)检测组织中RAB23表达情况,利用实时定量PCR(quantitative reverse transcription-PCR,qRT-PCR)检测组织中miR-802及RAB23 mRNA表达水平。结果:前列腺癌肿瘤组织较前列腺增生组织中miR-802表达水平降低(P<0.05),RAB23 mRNA及蛋白表达水平升高(P<0.05);前列腺癌患者肿瘤组织中miR-802及RAB23表达情况与患者T分期、淋巴结转移、Gleason评分、PSA水平有关(P<0.05);Kaplan-Meier生存分析表明,miR-802高表达患者3年总生存率高于miR-802低表达者(P<0.05);RAB23高表达患者3年总生存率显著低于RAB23低表达者(P<0.05);多因素分析表明,高Gleason评分、miR-802低表达、RAB23高表达是影响患者不良预后的独立危险因素(P<0.05);肿瘤组织miR-802及RAB23 mRNA表达水平负相关(P<0.05)。结论:前列腺癌肿瘤组织中miR-802低表达,RAB23蛋白高表达,均与患者T分期、淋巴结转移、Gleason评分、PSA水平、3年总生存率有关,高Gleason评分、miR-802低表达、RAB23高表达是影响患者不良预后的独立危险因素。 Objective:To detect the expressions of microRNA(miRNA)and RAB23 in prostate cancer tissues,and to analyze their relationships with clinicopathological features and prognosis.Methods:150 patients with prostate cancer who were diagnosed and treated by radical prostatectomy in our hospital from February 2011 to February 2014 were selected as the study subjects.150 patients with benign prostatic hyperplasia who underwent electrosurgical resection at the same time were selected as the control group.The expression of RAB23 in tissues was detected by immunohistochemistry(SP).Real-time quantitative polymerase chain reaction(qRT-PCR)was used to detect the expressions of miR-802 and RAB23 in tissues.Results:The expression of microRNA-802 in prostate cancer was lower than that in benign prostatic hyperplasia(P<0.05),and the expressions of RAB23 mRNA and protein were higher(P<0.05).The expressions of miR-802 and RAB23 in prostate cancer tissues were correlated with T stage,lymph node metastasis,Gleason score and PSA level(P<0.05).Kaplan-Meier survival analysis showed that the 3-year overall survival rate of patients with high expression of miR-802 was higher than that of patients with low expression of miR-802(P<0.05).The 3-year overall survival rate of patients with high expression of RAB23 was significantly lower than that of patients with low expression of RAB23(P<0.05).Multivariate analysis showed that high Gleason score,low expression of miR-802 and high expression of RAB23 were independent risk factors for adverse prognosis(P<0.05).The expression levels of miR-802 and RAB23 in tumor tissues were negatively correlated(P<0.05).Conclusion:The expression of miR-802 is low and RAB23 is high in prostate cancer tissues.They are related to T stage,lymph node metastasis,Gleason score,PSA level and 3-year overall survival rate.High Gleason score,low expression of miR-802 and high expression of RAB23 are independent risk factors for adverse prognosis.
作者 高永亮 张卫星 GAO Yongliang;ZHANG Weixing(Department of Urology,Xingyang People's Hospital,Henan Xingyang 450100,China;Department of Urology,First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450100,China)
出处 《现代肿瘤医学》 CAS 2021年第1期89-94,共6页 Journal of Modern Oncology
关键词 miR-802 RAB23 前列腺癌 临床病理参数 预后 miR-802 RAB23 prostate cancer clinicopathological parameters prognosis
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