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补肾健脾方对同种免疫型复发性自然流产患者的疗效分析

Analysis of the therapeutic effect of Bushen Jianpi formula on women with recurrent spontaneous abortion of the same immune type
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摘要 目的探讨使用补肾健脾方中医干预治疗封闭抗体阴性的同种免疫型复发性自然流产(recurrent spontaneous abortion,RSA)育龄期患者的疗效。方法纳入2016年1月至2018年1月于广州市花都区妇幼保健院诊断封闭抗体阴性的104例育龄期RSA患者,随机分为治疗组48例,对照组56例,治疗组采用中医孕前干预方法,以补肾健脾方(寿胎丸+四君子汤)为主方,辨证施治;对照组采取传统的淋巴细胞免疫治疗法。对比两组患者治疗后的妊娠情况及封闭抗体转阳率。结果治疗组妊娠率(93.75%)高于对照组(46.42%),两组比较差异有统计学意义(P<0.05)。治疗组患者封闭抗体由阴转阳率为81.25%,与对照组(89.28%)比较,差异无统计学意义(P>0.05)。结论补肾健脾方治疗RSA患者再次妊娠率明显高于单纯使用封闭抗体淋巴疗法患者,对封闭抗体转阳有一定疗效,但封闭抗体治疗不能改变妊娠结局。 Objective To investigate the therapeutic effect of Bushen Jianpi formula on patients of childbearing age with the same immune type recurrent spontaneous abortion(RSA) with negative blocking antibody.Methods 104 cases of women of reproductive age diagnosed with RSA with negative blocking antibody selected from Guangzhou Huadu District Maternal and Child Health Hospital were randomly divided into the treatment group(48 cases) and the control group(56 cases).The treatment group was treated with pre pregnancy intervention of traditional Chinese medicine,Bushen Jianpi formula(Shoutai pill + Sijunzi decoction) was the main prescription,and the treatment was based on syndrome differentiation.The control group received conventional lymphocyte immunotherapy.The pregnancy status and the positive conversion rate of blocking antibody in the two groups were compared.Results The pregnancy rate of the treatment group(93.75 %) was higher than that of the control group(46.42 %),and the difference was statistically significant(P<0.05).The rate of negative to positive conversion of blocking antibody in the treatment group was 81.25 %,compared with 89.28 % in the control group,with no significant difference(P>0.05).Conclusion The repregnancy rate of Bushen Jianpi formala in the treatment of RSA patients is significantly higher than that of using blocking antibody lymph therapy alone,which has a certain effect on blocking antibody negative conversion to positive,but blocking antibody treatment cannot change the pregnancy outcome.
作者 贾金平 汪莎 JIA Jinping;WANG Sha(Department of Obstetrics,Guangzhou Huadu District Maternal and Child Health Hospital,Guangzhou Guangdong 510800,P.R.China)
出处 《中国计划生育和妇产科》 2020年第7期55-56,61,共3页 Chinese Journal of Family Planning & Gynecotokology
基金 2017年广东省中医药管理局课题(项目编号:20172117)。
关键词 复发性流产 中医 疗效 封闭抗体 recurrent abortion traditional Chinese medicine curative effect blocking antibody
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