期刊文献+

血浆同型半胱氨酸与冠脉狭窄程度及病变支数的相关性研究 预览

Correlation between plasma homocysteine and severity of coronary artery stenosis and number of lesions branch
在线阅读 下载PDF
收藏 分享 导出
摘要 目的探讨血浆同型半胱氨酸(Hcy)与冠脉狭窄程度及病变支数的相关性。方法回顾性纳入2018年1月至2018年9月重庆医科大学附属永川医院已行冠状动脉造影且结果为阳性的冠脉狭窄病人103例,根据血浆Hcy水平将其分为高同型半胱氨酸组(HHcy,Hcy≥10μmol/L)71例和正常同型半胱氨酸组(NHcy,Hcy<10μmol/L)32例,所有纳入病人均完善血浆同型半胱氨酸、尿酸以及血脂检测,采用冠脉Gensini评分评估冠脉狭窄程度。结果 HHcy组的平均收缩压[(140±20)mmHg比(136±19)mmHg,P=0.381)]、平均舒张压[(84±13)mmHg比(83±13)mmHg,P=0.752)]、尿酸[(413.0±130.6)μmol/L比(346.0±97.8)μmol/L,P=0.012)]、总胆固醇[(4.4±1.0)mmol/L比(4.1±1.1)mmol/L,P=0.216)]、总三酰甘油[(1.6±0.9)mmol/L比(1.5±0.7)mmol/L,P=0.741)]及低密度脂蛋白胆固醇水平[(2.5±0.8)mmol/L比(2.3±0.9)mmol/L,P=0.129)]均高于NHcy组,冠脉Gensini评分与Hcy及低密度脂蛋白胆固醇水平呈正相关(r=0.2,0.2;p=0.012,0.012),Hcy水平能显著影响冠脉Gensini评分,且Hcy水平越高,冠脉Gensini评分越高(相关系数=0.804,P=0.015);NHcy组冠脉单支病变占50%,双支病变占40.6%,三支病变占9.4%,HHcy组中单支病变占25.4%,双支病变占33.8%,三支病变占40.8%(χ2=11.38,P=0.03)。结论血浆Hcy水平及低密度脂蛋白胆固醇与冠脉狭窄程度呈正相关,但相关性较弱,高水平的同型半胱氨酸是冠脉严重病变的独立危险因素,且会增加冠脉三支病变的发生率。 Objective To investigate the correlation between plasma homocysteine(Hcy)and coronary stenosis and the number of lesions branch.Methods 103 patients who undergone coronary angiography with positive results in Yongchuan Hospital Affiliated to Medical University of Chongqing from Jan. 2018 to Sep. 2018 were retrospectively divided into high homocysteine group(HHcy,Hcy<10 μmol/L,n=71)and normal homocysteine group(NHcy,Hcy<10 μmol/L,n=32)according to the level of plasma Hcy.All patients underwent plasma Hcy,uric acid and blood lipids.The coronary Gensini score was used to assess the degree of coronary stenosis.Results Compared with NHcy group,the mean systolic blood pressure[(140±20)mmHg vs.(136±19)mmHg,P=0.381)],mean diastostolic blood pressure[(84±13)mmHg vs.(83±13)mmHg,P=0.752),serum uric acid(413.0±130.6)μmol/L vs.(346.0±97.8)μmol/L,P=0.012)]total cholesterol[(4.4±1.0)mmol/L vs.(4.1±1.1)mmol/L,P=0.216)],triglyceride[(1.6±0.9)mmol/L vs.(1.5±0.7)mmol/L,P=0.741)]and low density lipoprotein cholesterol levels[(2.5±0.8)mmol/L vs.(2.3±0.9)mmol/L,P=0.129)were higher in HHcy group.Coronary Gensini score was positively correlated with Hcy and low density lipoprotein cholesterol levels(r=0.2,0.2;P=0.012,0.012).Hcy level can significantly affect the coronary Gensini score,and the higher the Hcy level,the higher the coronary Gensini score(β=0.804,P=0.015).In NHcy group,50% were single vessel lesions,40.6% were double vessel lesions,and 9.4% were triple vessel lesions;In NHcy group,25.4% were single vessel lesions,33.8% were double vessel lesions,and 40.8% were triple vessel lesions(χ2=11.38,P=0.03).Conclusion The level of plasma Hcy and low density lipoprotein cholesterol are positively correlated with the degree of coronary stenosis,but the correlation is weak.High levels of Hcy is an independent risk factor for severe coronary artery disease,and increase the incidence of triple vessel lesions of coronary artery.
作者 沈治利 李芝峰 SHEN Zhili;LI Zhifeng(Department of Cardiology,Yongchuan Hospital Affiliated to Medical University of Chongqing,Chongqing 402160,China)
出处 《安徽医药》 CAS 2020年第2期316-319,共4页 Anhui Medical and Pharmaceutical Journal
关键词 冠心病 冠状动脉狭窄 胆固醇 脂蛋白类 LDL 半胱氨酸 相关性 Coronary disease Coronary stenosis Cholesterol Lipoproteins,LDL Homocysteine Correlation analysis
  • 相关文献
投稿分析
职称考试

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈