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704例注射用头孢曲松钠不良反应及潜在风险分析 预览

Adverse Reactions and Potential Risks Induced by Ceftriaxone Sodium for Injection: An Analysis of 704 Cases
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摘要 目的探讨头孢曲松钠合并用药致不良反应(ADR)的发生情况及合理性,为临床安全用药提供参考。方法对河北省药品监测评价中心2012年至2016年收集的704例注射用头孢曲松钠合并用药所致ADR报告进行回顾性分析。结果头孢曲松钠与氨基苷类抗生素、高效利尿药(呋塞米)、抗病毒药阿昔洛韦联合使用可能增加肾毒性风险;与含乙醇类药物联用有增加双硫仑样反应的风险;与含钙制剂不能混用或不能同时输注,有致死风险。结论应关注头孢曲松钠合并用药的合理性及潜在风险,加强用药监测,防治严重ADR。 Objective To investigate the occurrence and rationality of the adverse drug reaction( ADR) induced by ceftriaxone sodium combined with other drugs,and to provide reference for clinical safety use of drugs. Methods The 704 cases of ADR reports induced by Ceftriaxone Sodium for Injection combined with other drugs and collected by the Center for Drug Monitoring and Evaluation of Hebei from 2012 to 2016 were analyzed retrospectively. Results Ceftriaxone sodium combined with aminoglycoside antibiotics,high-efficiency diuretics such as furosemide and antiviral drug such as acyclovir might increase the risk of nephrotoxicity. Ceftriaxone sodium combined with alcohol-containing drugs might increase the risk of disulfiram-like reactions. Ceftriaxone sodium couldn’t be mixed with calcium-containing preparations or infusion at the same time,which had the risk of death. Conclusion Attention should be paid to the rationality and potential risks of ceftriaxone sodium combined with other drugs,and drug monitoring should be strengthened to prevent severe ADR.
作者 李永辉 王芳 郭瑞锋 LI Yonghui;WANG Fang;GUO Ruifeng(Center for Drug Monitoring and Evaluation of Hebei,Shijiazhuang,Hebei,China 050090)
出处 《中国药业》 CAS 2019年第21期80-83,共4页 China Pharmaceuticals
基金 河北省食品药品监督管理局2014年度食品药品安全科技项目计划[ZD2014009].
关键词 头孢曲松钠 药物联用 药品不良反应 风险 合理用药 ceftriaxone sodium drug combination adverse drug reaction risk rational drug use
作者简介 第一作者:李永辉,男,硕士研究生,副主任药师,研究方向为药品不良反应监测与评价,(电子信箱)hbfda157@126.com;通信作者:郭瑞锋,男,硕士研究生,主任药师,研究方向为药品不良反应监测与评价,(电子信箱)2290221538@qq.com.
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