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药物性肝损伤临床诊断的研究进展 预览

Research Progress in Clinical Prognosis of Idiosyncratic Drug-induced Liver Injury
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摘要 随着药品的开发与利用,药物性肝损伤(DILI)的病例在临床上逐渐被发现。各国研究者们通过调查临床病例,总结出DILI诊断过程中出现的临床分型和临床表现,发现大多数DILI患者属于特异质型。但由于个体间发病原因千差万别,病例的临床表现复杂多变,且DILI的诊断方式属排他性诊断,仍需要利用因果关系评估进行判别,因此,很多用药后出现肝功能异常的患者依然难以明确其具体病因。临床病例研究中通过不断收集DILI风险的药物信息,实验室研究中不断发现多种新型生物标志物,以期在未来的应用中能够为DILI疑似病例提供有效帮助。 With the development and utilization of drugs,the cases of drug-induced liver injury( DILI) have been gradually discovered during clinical treatment. By investigating clinical cases,researchers in different countries summarized the clinical classification and manifestations of DILI diagnosis,and found that many DILI patients belong to idiosyncratic type.However,the causes are widely various among individuals,and the clinical manifestations are also complex. And the method of diagnosis is an exclusive diagnosis,which still needs judgement by causal assessment. Therefore,it is still difficult to identify the specific cause of abnormal liver function after medication. By continuously collecting drug information on the risk of liver damage,and continuous discovery of new biomarkers in laboratory,it’ s expected to provide effective help for DILI differential diagnosis in the future.
作者 解鑫赫 赵瑞玲 XIE Xinhe;ZHAO Ruiling(School of Pharmacy,Shanxi Medical University,Taiyuan 030001,China;Department of Pharmacy,Children′s Hospital of Shanxi,Taiyuan 030013,China)
出处 《医学综述》 2019年第20期4044-4048,4054共6页 Medical Recapitulate
关键词 药物性肝损伤 临床诊断 诊断标准 生物标志物 Drug-induced liver injury Clinical diagnosis Diagnostic criteria Biomarker
作者简介 通信作者:赵瑞玲,E-mail:ruiling.zhao@163.com.
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