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夏蛎金消颗粒联合化疗治疗中晚期非小细胞肺癌临床研究 预览

Clinical Study of Xiali Jinxiao Granule Combined with Chemotherapy in Treatment of Advanced Non-small-cell Lung Cancer
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摘要 目的:研究夏蛎金消颗粒联合化疗治疗中晚期非小细胞肺癌(NSCLC)的疗效和安全性。方法:最终入组的66例中晚期NSCLC患者分为治疗组(33例)和对照组(33例)。治疗组采用院内协定方夏蛎金消颗粒联合DP(多西紫杉醇+顺铂)或GP(吉西他滨+顺铂)化疗方案,对照组单纯采用DP或GP化疗方案,2组均连续用药2周期(21 d为1周期)。第1周期化疗开始时给夏蛎金消颗粒,每周6剂,连续服用6周。2组均以21 d为1个周期,2周期末评价疗效。结果:治疗组治疗后患者血小板及白细胞降低、肝功能异常、消化道反应发生率均明显低于对照组,差异有显著性(P<0.05)。治疗组与对照组治疗前卡氏评分(KPS)分别为(75.58±6.81)和(74.00±6.81),2组治疗后KPS评分分别为(80.72±6.48)和(76.88±6.76),与各自治疗前相比明显升高(P<0.05);治疗组高于对照组(P<0.05)。治疗组与对照组治疗后中医临床证候与治疗前比较明显减轻(P<0.05);治疗组优于对照组(P<0.05)。结论:夏蛎金消颗粒能明显降低化疗的毒副反应,改善临床症状,提高患者生活质量,中药联合化疗具有一定优势。 Objective: To study the efficacy and safety of Xiali Jinxiao Granule combined with chemotherapy in the treatment of advanced non-small-cell lung cancer (NSCLC).Methods: Sixty-six patients with advanced NSCLC were divided into treatment group (33 cases) and control group (33 cases).The treatment group was given Xiali Jinxiao Granule combined with DP (docetaxel + cisplatin) or GP (gemcitabine + cisplatin) chemotherapy regimen, while the control group was given DP or GP chemotherapy regimen alone . Both groups were treated for two cycles (21 days for one cycle). At the beginning of the first cycle of chemotherapy, Xiali Jinxiao Granule was administrated 6 doses a week for 6 weeks. The therapeutic effect was evaluated at the end of the 2 nd cycle in both groups. Results: After treatment, the incidence of platelet and leukocyte decrease, liver dysfunction and digestive tract reaction in the treatment group were significantly lower than those in the control group ( P <0.05).The KPS scores of the treatment group and the control group before treatment were (75.58±6.81) and (74.00±6.81), respectively.After treatment, the KPS scores of the two groups were (80.72±6.48) and (76.88±6.76), which were significantly higher than those before the treatment ( P <0.05), and score of the treatment group was higher than that of the control group ( P <0.05).The clinical syndrome in both groups were significantly alleviated after treatment ( P <0.05), and the treatment group was better than the control group ( P <0.05).Conclusion: Xiali Jinxiao Granule can significantly reduce the toxicity and side effects of chemotherapy, improve clinical symptoms, and improve the quality of life of patients.Chinese medicine combined with chemotherapy has certain advantages.
作者 范焕芳 王峥嵘 闫娇娇 李德辉 孙春霞 马盼 邢紫阳 FAN Huan-fang;WANG Zheng-rong;YAN Jiao-jiao;LI De-hui;SUN Chun-xia;MA Pan;XING Zi-yang(Department of Oncology,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050011)
出处 《河北中医药学报》 2019年第5期19-22,共4页 Journal of Hebei Traditional Chinese Medicine and Pharmacology
基金 河北省重点研发计划资助项目:No.172777215.
关键词 非小细胞肺癌 肺胀 肺积 肺痿 夏蛎金消颗粒 化疗 疗效评价 Non-small-cell lung cancer Lung distention Pulmonary retention Lung atrophy Xiali Jinxiao Granule Chemotherapy Therapeutic effect evaluation
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