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氢化可的松治疗小儿难治性肺炎支原体肺炎的临床疗效及对炎症水平的影响 预览

Clinical efficacy of hydrocortisone in the treatment of refractory pneumonia mycoplasma pneumonia in children and its effect on inflammation
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摘要 目的探讨氢化可的松治疗小儿难治性肺炎支原体肺炎的临床疗效及对炎症水平的影响。方法将2017年2月至2019年2月于本院接受诊治的80例难治性肺炎支原体肺炎患儿,依据随机数表法分为两组,各40例。对照组应用阿奇霉素治疗,研究组予以阿奇霉素联合氢化可的松治疗。对比两组临床症状、体征消失时间、治疗前后炎症水平[C反应蛋白(CRP)、降钙素原(PCT)]变化及不良反应发生率。结果研究组肺部啰音消失时间、退热时间、咳嗽消失时间、X线肺部阴影消失时间、喘息消失时间均短于对照组,差异有统计学意义(P<0.05);相较于治疗前,治疗2周后两组血清CRP、PCT表达均降低,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良反应总发生率略高于对照组,差异无统计学意义。结论氢化可的松治疗小儿难治性肺炎支原体肺炎的临床疗效显著,能进一步缓解患儿临床症状/体征,减轻炎症水平,不良反应少,值得推广。 Objective To investigate the clinical efficacy of hydrocortisone in the treatment of refractory pneumonia caused by pneumonia and its effect on inflammation. Methods 80 children with refractory pneumonia mycoplasma pneumonia who were treated in our hospital from February 2017 to February 2019 were divided into two groups according to the random number table method, 40 cases in each group. The control group was treated with azithromycin, and the study group was treated with azithromycin combined with hydrocortisone. The disappearance time of clinical symptoms/signs, the level of inflammation before and after treatment [C-reactive protein (CRP), procalcitonin (PCT)] and the incidence of adverse reactions were compared. Results The disappearance time, fever time, disappearance time of cough, disappearance time of X-ray lung shadow and disappearance time of wheezing in the study group were shorter than those in the control group, the difference was statistically significant (P<0.05). Compared to before treatment, the serum CRP and PCT expressions of the two groups were decreased after 2 weeks of treatment, and the study group was lower than that of the control group (P<0.05). The total incidence of adverse reactions in the study group was slightly higher than that of the control group. The difference was not statistically significant. Conclusion The clinical efficacy of hydrocortisone in the treatment of refractory pneumonia mycoplasma pneumonia in children is significant, which can further alleviate the clinical symptoms/signs of children, reduce the level of inflammation, and have fewer adverse reactions. It is worth promoting.
作者 陈建群 崔倪 万晓龙 李军 陈阳 朱志萍 Chen Jianqun;Cui Ni;Wan Xiaolong;Li Jun;Chen Yang;Zhu Zhiping(Department of Pediatrics, Dongtai Hospital, Nantong University, Yancheng, Jiangsu, 224200, China;Department of Pediatrics, Nanjing Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, Jiangsu, 210014, China)
出处 《当代医学》 2019年第29期52-54,共3页 Contemporary Medicine
关键词 氢化可的松 难治性肺炎支原体肺炎 炎症水平 Hydrocortisone Refractory pneumonia mycoplasma pneumonia Inflammation level
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