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益肾通络泄毒方联合羟苯磺酸钙治疗糖尿病肾病的疗效及对APN、CysC指标的影响 预览

Effect of Yishen Tongluo decoction combined with calcium hydroxybenzenesulfonate on diabetic nephropathy and its influence on APN and CysC
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摘要 目的分析益肾通络泄毒方联合羟苯磺酸钙治疗糖尿病肾病的疗效及对血清脂联素(APN)、胱抑素C(CysC)指标的影响。方法将88例糖尿病肾病患者随机分为观察组(n=44)和对照组(n=44)。在常规治疗的基础上,对照组行羟苯磺酸钙治疗,观察组行益肾通络泄毒方联合羟苯磺酸钙治疗。评价两组患者的临床治疗效果;并检测两组患者治疗前后的24 h尿蛋白定量(24 h UP)、血清α微球蛋白(α-MG)、血清肌酐(SCr)和血清APN、CysC指标。结果观察组患者的临床治疗总有效率90.91%高于对照组77.27%(χ^2=7.37,P<0.05)。两组患者治疗后的24 h UP、α-MG、SCr、CysC指标值均低于治疗前,APN高于治疗前(t分别=6.36、7.35、7.72、7.02、7.02、6.89、7.56、7.13、7.28、-7.23,P均<0.05),且观察组治疗后的24 h UP、α-MG、SCr、CysC指标值均低于对照组治疗后,APN指标值高于对照组治疗后(t分别=7.37、7.11、8.03、7.23、-7.12,P均<0.05)。结论益肾通络泄毒方联合羟苯磺酸钙治疗糖尿病肾病的疗效较好,能有效改善血清APN、CysC指标水平,从而改善患者肾功能和胰岛功能。 Objective To analyze the effect of Yishen Tongluo decoction combined with calcium hydroxybenzenesulfonate on diabetic nephropathy and its effect on serum adiponectin(APN)and cystatin C(CysC).Methods Totally 88 cases of diabetic nephropathy were randomly divided into observation group and control group with 44 cases in each.On the basis of routine treatment,the control group was treated with calcium hydroxybenzenesulfonate.The observation group was received Yishen Tongluo decoction combined with calcium hydroxybenzenesulfonate.The clinical therapeutic effects of the two groups were evaluated.The 24 h urine protein level(24 h UP),serum α microglobulin(α-MG),serum creatinine(SCr)and serum APN,CysC parameters were measured before and after treatment.Results The total effective rate of clinical treatment was 90.91% in the observation group and 77.27% in the control group.The difference was statistically significant(χ^2=7.37,P<0.05).After treatment,the 24 h UP,α-MG,SCr,and CysC levels of the two groups were lower than those before treatment,and APN was higher than before treatment.The differences were statistically significant(t=6.36,7.35,7.72,7.02,7.02,6.89,7.56,7.13,7.28,-7.23,P<0.05).After treatment,the 24 h UP,α-MG,SCr,and CysC levels of the observation group were lower than those of the control group,while the APN index was higher than that of the control group(t=7.37,7.11,8.03,7.23,-7.12,P<0.05).Conclusion Yishen Tongluo decoction combined with western medicine is effective in the treatment of diabetic nephropathy,which can effectively improve serum APN and CysC levels,thus improve renal function and islet function.
作者 黄科 HUANG Ke(Department of Nephrology,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314000,China)
出处 《全科医学临床与教育》 2019年第8期722-724,共3页 Clinical Education of General Practice
关键词 糖尿病肾病 益肾通络泄毒方 肾功能 脂联素 胱抑素C diabetic nephropathy Yishen Tongluo decoction renal function APN CysC
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