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浅谈小儿过敏性紫癜诊治的临床体会 预览

Clinical experience of diagnosis and treatment of Henoch-Schonlein Purpura in Children
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摘要 目的:对地塞米松与甲强龙治疗小儿过敏性紫癜的临床效果进行分析与探讨。方法:选择我院自2016年4月至2018年11月收治的腹型过敏性紫癜患儿54例作为本次研究对象,依据患儿入院顺序的奇偶性对其展开交叉分组,将其中一组命名为对照组并应用甲强龙治疗方案,将另一组命名为研究组并应用地塞米松治疗方案,观察两组患儿的疾病治疗效果与不良反应发生情况。结果:研究组中96.30%(26/27)患儿治疗有效,相较于对照组患儿的治疗有效率77.78%(21/27)更高;研究组中7.41%(2/27)患儿发生不良反应,显著低于对照组患儿的不良反应发生率29.63%(8/27),利用统计方法计算后得出两组数据具有显著差异(P<0.05)。结论:与甲强龙治疗方案相比,地塞米松治疗方案对腹型过敏性紫癜患儿的疾病治疗效果更好,患儿所面临的用药后不良反应发生风险亦较低,具有较为广阔的临床应用前景。 Objective: to analyze and discuss the clinical effect of dexamethasone and methylprednisolone in the treatment of Henoch-Schonlein purpura in children. Methods: fifty-four children with abdominal Henoch-Schonlein purpura treated in our hospital from April 2016 to November 2018 were selected as the subjects of this study. The children were divided into two groups according to the parity of admission order. One group was named control group and treated with methylprednisolone, and the other group was named study group and treated with dexamethasone. The therapeutic effect and adverse reactions of the two groups were observed. Results: 96.30%(26 / 27) of the patients in the study group were effective, which was higher than that of the control group (77.78%, 21 / 27), and 7.4 in the study group. The incidence of adverse reactions in 1%(2 / 27) children was significantly lower than that in the control group (29.63%(8 / 27). The statistical analysis showed that there was significant difference between the two groups (P < 0.05). Conclusion: compared with methylprednisolone regimen, dexamethasone therapy is more effective in the treatment of abdominal Henoch-Schonlein purpura, and the risk of adverse reactions after administration of dexamethasone is also lower, so it has a broad prospect of clinical application in children with abdominal Henoch-Schonlein purpura.
作者 钟秋菊 Qiuju ZHONG(不详)
出处 《医学研究》 2019年第2期53-55,共3页
关键词 小儿腹型过敏性紫癜 地塞米松 甲强龙 治疗效果 abdominal Henoch-Schonlein purpura in children dexamethasone methylprednisolone therapeutic effect
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