Objective: to analyze and discuss the clinical effect of dexamethasone and methylprednisolone in the treatment of Henoch-Schonlein purpura in children. Methods: fifty-four children with abdominal Henoch-Schonlein purpura treated in our hospital from April 2016 to November 2018 were selected as the subjects of this study. The children were divided into two groups according to the parity of admission order. One group was named control group and treated with methylprednisolone, and the other group was named study group and treated with dexamethasone. The therapeutic effect and adverse reactions of the two groups were observed. Results: 96.30%(26 / 27) of the patients in the study group were effective, which was higher than that of the control group (77.78%, 21 / 27), and 7.4 in the study group. The incidence of adverse reactions in 1%(2 / 27) children was significantly lower than that in the control group (29.63%(8 / 27). The statistical analysis showed that there was significant difference between the two groups (P < 0.05). Conclusion: compared with methylprednisolone regimen, dexamethasone therapy is more effective in the treatment of abdominal Henoch-Schonlein purpura, and the risk of adverse reactions after administration of dexamethasone is also lower, so it has a broad prospect of clinical application in children with abdominal Henoch-Schonlein purpura.
abdominal Henoch-Schonlein purpura in children