Objective To study the effect of Laparoscope nephron-sparing surgery (MNSS) on CD105, CD146 and CK19 of patients with renal carcinoma. Methods96 patients with renal carcinoma treated in East Hospital, Sichuan Provincial People's Hospital, Sichuan Academy of Med from January 2013 to November 2014 were selected, and divided into MNSS group ( n =48) and RN group ( n =48) according to the random number table method. Patients in RN group were performed radical nephrectomy (RN), and those in SS group were performed MNSS. The operation related indicators, the levels of serum creatinine before operation and 1d, 90d and 1 year after operation, serum levels of CD105, CD146 and CK19 and the tumor-free survival situation 3 years after operation of the two groups were observed. ConclusionThe intraoperative blood loss and operation time in MNSS group were greater than those in RN group, and the postoperative drainage time and postoperative hospital stay were less than those in RN group( P < 0.05 ). The levels of serum creatinine 1d, 90d and 1 year after operation in MNSS group were lower than those in RN group ( P < 0.05). At 90d after operation, the serum levels of CD105, CD146 and CK19 in the two groups were lower than those before operation ( P < 0.05), and the difference in the serum levels of CD105, CD146 and CK19 between the two groups was not statistically significant ( P > 0.05). At 3 years after operation, there was no significant difference in disease free survival rate between MNSS group (83.33%) and RN group (87.50%)( P > 0.05);ConclusionMNSS can preserve renal function and reduce serum levels of CD105, CD146 and CK19 in treating patients with renal carcinoma.
Medical Journal of West China