目的:分析复发性口腔溃疡(recurrent aphthous ulcer,RAU)和幽门螺杆菌(Helicobacter pylori,Hp)感染的相关性,以及RAU患者的叶酸、维生素B12(vitamin B12,Vit B12)和铁蛋白缺乏情况与Hp感染之间的相关性.方法:对118例RAU患者和142例健康对照者进行13C-尿素呼气试验和血清叶酸、铁蛋白和维生素B12浓度检测,并进行统计学分析.结果:Hp感染阳性率在RAU组和健康对照组间无明显差异(P=0.389).RAU组中叶酸、Vit B12和铁蛋白缺乏率均高于对照组;但仅Vit B12缺乏率在两组间存在显著性差异(P<0.001).对两组进行比较发现,RAU组中叶酸、Vit B12和铁蛋白缺乏者的Hp阳性率均低于对照组,但无统计学差异.多因素回归分析表明Hp感染和RAU发病无明显相关性(P=0.954).结论:Hp感染和RAU发病可能并无直接的因果关系.研究Hp感染和RAU的内在联系机制,不应该仅局限在Vit B12等缺乏的方面,还应该涵盖可能相关的免疫机制.
Objective: To analysis the relationship between the recurrent aphthous ulcer ( RAU) and gastric Helicobacter pylori(Hp) infection, and the possible relationship between the hematinic deficiencies( folate, vitamin B12 and ferritin) of RAU patients and their gastric Hp infection. Methods: Totally 118 RAU patients and 142 heathy controls were enrolled in the present study. For each participant,^13C-Urea Breath Test (^13 C-UBT) were performed and serum folate, vitamin B12 and ferritin levels were detected. These collected data were statistically analyzed. Results: No statistically difference of Hp infection rate was observed between RAU patients and healthy controls(P = 0. 389). Comparing with the healthy controls, the frequency of hematinic deficiencies( folate, vitamin B12 and ferritin) were all elevated in RAU patients, only the vitamin B12 deficiency was statistically significant(P<0. 001). Comparing to the corresponding healthy controls, the Hp infection rates of RAU patients with folate, vitamin B12 and ferritin deficiency were all lower, but without statistically significant. The multi-logistic regression analysis showed no correlation between gastric Hp infection and RAU ( P = 0. 954). Conclusion: There may not be direct casual relationship between gastric Hp infection and RAU. The underlying mechanisms may be not only limited to Vitamin B12 deficiency, but also involve immune-related abnormalities.
Journal of Clinical Stomatology