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原发性甲状腺功能亢进症并甲状腺癌的临床分析

Clinical analysis of primary hyperthyroidism complicated with thyroid carcinoma
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摘要 目的分析原发性甲状腺功能亢进症(甲亢)并甲状腺癌的临床病理特征.方法回顾性分析2010年1月至2018年7月在厦门大学附属第一医院接受甲状腺切除术的甲状腺癌患者418例的临床病理资料,依据甲状腺功能分为两组,A组(n=39)甲亢,B组(n=379)甲状腺功能正常.分析并比较两组的临床病理特征.结果两组年龄、性别、肿瘤分期、肿瘤直径差异均无统计学意义(均P>0.05);A组淋巴结转移率为17.9%(7/39),高于B组的6.1%(23/379)(χ2=5.814,P=0.016).A组术后暂时性甲状旁腺功能减退发生率为28.2%(11/39),高于B组的13.2%(50/379)(χ2=6.394,P<0.05);A组局部复发率为5.1%(2/39),高于B组的2.4%(9/379),但差异无统计学意义(χ2=0.248,P=0.619);A组5年无病生存率为84.6%(33/39),低于B组的95.8%(363/379)(χ2=6.740,P<0.05).结论甲亢合并甲状腺癌具有较高侵袭性行为,应采取积极的治疗方法. Objective To analyze the clinicopathological features of primary hyperthyroidism complicated with thyroid carcinoma. Methods From January 2010 to July 2018,418 patients complicated with thyroid cancer underwent thyroidectomy in the First Affiliated Hospital of Xiamen University were retrospectively analyzed. According to thyroid function,418 patients were divided into two group:A group( n = 39) had hyperthyroidism with thyroid carcinoma,and B group(n = 379) had normal thyroid function. The clinicopathological features of the two groups were analyzed and compared. Results There were no statistically significant differences in age,sex,tumor stage and tumor diameter between the two groups(all P > 0. 05). The lymph node metastasis rate in A group was 17. 9%(7 /39), which was higher than that in B group[6. 1%(23 /379)](χ2 = 5. 814,P = 0. 016). The incidence rate of temporary hypoparathyroidism in A group was 28. 2%(11 /39), which was higher than that in B group[13. 2%(50 /379)](χ2 = 6. 394,P < 0. 05). The local recurrence rate in A group was 5. 1%(2 /39),which was higher than that in B group[2. 4%(9 /379)],but there was no statistically significant difference(χ2 = 0. 248,P = 0. 619). The 5 - year disease - free survival rate in A group was 84. 6%( 33 /39), which was lower than that in B group [ 95. 8%(363 /379)](χ2 = 6. 740,P < 0. 05). Conclusion Hyperthyroidism complicated with thyroid carcinoma has high aggressive behavior and should be treated actively.
作者 汪丽平 蔡成福 刘存山 Wang Liping;Cai Chengfu;Liu Cunshan(Department of Otolaryngology Head and Neck surgery,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian 361003,China)
出处 《中国基层医药》 CAS 2019年第14期1686-1688,共3页 Chinese Journal of Primary Medicine and Pharmacy
关键词 甲状腺功能亢进症 甲状腺肿瘤 甲状腺功能试验 甲状腺功能减退症 肿瘤分期 淋巴转移 肿瘤复发 局部 存活率 病理学 临床 Hyperthyroidism Thyroid neoplasms Thyroid function tests Hypothyroidism Neoplasm staging Lymphatic metastasis Neoplasm recurrence,local Survival rate Pathology,clinical
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