Objective To compare the effects and anti-inflammatory effects of three kinds of extracts of Cihang Dan prescription (molecular weight no more than 1 000 Da) on mouse dysmenorrhea model. Methods The effects of Cihang Dan prescription by the extracts of three methods on dysmenorrhea model induced by oxytocin and prostaglandin PGE1, and the effect on ear swelling and cotton granuloma in rats were compared. Results Compared with the control group, the extracts from the three methods of Cihang Dan prescription significantly inhibited dysmenorrhea and anti-inflammatory effects, the difference was statistically significant (P < 0.01). There were also significant differences between AE group and WE group compared with SBE group, the difference was statistically significant (P < 0.05). The effects were as follows: SBE group > AE group > WE group. Conclusion The three methods of Cihang Dan prescription can significantly inhibit the dysmenorrhea induced by drugs and have antiinflammatory effects. Among them, SBE group has the strongest inhibition of dysmenorrhea and anti-inflammatory.
China Health Standard Management
Cihang Dan prescription
small molecule water extract
method of extraction