Objective To investigate the correlation between functional dyspepsia and anxiety and depression.Methods Sixty patients who were diagnosed by Rome III standard in Department of Digestion,Wuhan Hospital of Integrated Traditional Chinese and Western Medicine from January to December 2015 were selected as FD group(FD) by random number table method.At the same time,22 healthy volunteers were recruited as HS group(HS).FD group was differentiated by TCM syndrome,there were 28 cases of spleen deficiency qi stagnation,17 cases of spleen deficiency and dampness,15 cases of spleen Yang deficiency type.All subjects were evaluated with symptom scale and Hospital anxiety and depression scale(HAD).Results(1) The anxiety(9.31±2.23 vs.8.22±2.07) and depression(10.17±2.30 vs.8.63±1.81) scores of FD group were higher than those in the HS group,and the differences were statistically significant(P=0.049,0.015).(2) The syndrome differentiation of FD patients with spleen deficiency and qi stagnation(10.59±2.01 vs.9.40±1.72) was higher than that in the spleen deficiency and dampness obstruction(P=0.048) and spleen yang deficiency(9.27±1.23)(P=0.033).The depression score with spleen deficiency and qi stagnation(10.75±2.65) was significantly higher than that of the spleen deficiency and dampness obstruction(9.24±1.75)(P=0.014).(3) The syndrome differentiation was positively correlated with anxiety and depression in FD patients with spleen deficiency and spleen deficiency type FD(rs=0.61,0.53,0.63,0.57,P<0.05).Conclusion Most of the patients with functional dyspepsia are accompanied by anxiety and depression,and the loss of spleen and health is the key to the disease.The syndrome differentiation should be based on the application of invigorating spleen and nourishing the spirit of god.
Anhui Medical and Pharmaceutical Journal
Cold-Dampness impairing spleen
Lunh spleen concur defic
Reinforcing Qi strength spleen
Hospital anxiety and depression scale