滤过泡瘢痕化是导致青光眼滤过术失败的主要原因。目前,临床上多应用结膜下注射丝裂霉素及5-氟尿嘧啶等抗代谢药物以减少瘢痕化的发生,一定程度上提高了手术成功率,但其伴随的细胞毒性等不良反应不可忽视。富含半胱氨酸的酸性分泌蛋白(secreted protein acidic and rich in cysteine,SPARC)作为一种基质细胞蛋白在眼内广泛分布,在创伤修复和组织重塑的过程中发挥重要作用。结膜下瘢痕化的小鼠模型中可观察到SPARC表达明显升高。研究表明SPARC可通过多种途径参与并调控滤过泡瘢痕化的形成,有望成为抗瘢痕化治疗的特异性新靶点。
Filtering bleb scarring is the main cause of glaucoma filtration surgery failure.Subconjunctival injection of antimetabolites,such as mitomycin and 5-fluorouracil,is widely used clinically to reduce the incidence of scarring,which improves the success rate of the surgery.However,accompanied side effects such as cytotoxicity should not be ignored.Secreted protein acidic and rich in cysteine (SPARC) as a matricellular protein is widely distributed in the eyes,which plays an important role in the process of wound repairing and tissue remodeling.The expression of SPARC is significantly elevated in the mouse model of subconjunctival scarring.Researches suggest that SPARC participates in and regulate the formation of bleb scarring through multiple pathways,therefore it may become a specific new target in the anti-scarring therapy.
Journal of Shanghai Jiaotong University:Medical Science
secreted protein acidic and rich in cysteine (SPARC)
glaucoma filtration surgery