Objective To investigate the protective effect of MnTBAP on early brain injury following subarachnoid hemorrhage in rat model. Methods 100 SD rats were randomly divided into four groups: the blank control group,the sham operation group,the model group (SAH) and the experimental group (SAH+MnTBAP),25 rats per group.The difference among these groups of the neurological deficit score,brain water content,blood-brain barrier permeability (Evans blue extravasation test),ATPase-6 and cytochrome C protein expression,MDA,SOD and GSH-Px active level was observed 24 h after SAH. Results Compared with the model group,the neurological deficit score was significantly increased,brain water content was significantly decreased,blood-brain barrier permeability was significantly decreased,ATPase-6 protein expression was significantly increased,cytochrome C protein expression was significantly decreased,MDA content was significantly decreased,SOD and GSH-Px activity were significantly increased in the experimental group. Conclusion MnTBAP can improve neurological function and protect mitochondria.MnTBAP may play a neuroprotective role in early brain injury following SAH.
Acta Universitis Medicinalis Anhui