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万古霉素对MARS所致腹膜透析相关性腹膜炎的疗效 预览

Efficacy of Vancomycin on Peritoneal Dialysis Related Peritonitis Caused by Methicillin-resistant Staphylococcus Aureus
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摘要 目的探讨不同药物治疗耐甲氧西林金黄色葡萄球菌(MARS)所致腹膜透析相关性腹膜炎的疗效差异。方法收集我院耐甲氧西林金黄色葡萄球菌所致腹膜透析相关性腹膜炎的患者分为:研究组(给予万古霉素治疗)与对照组(给予利奈唑胺治疗)。对比两组患者治疗前后腹水渗出液细胞成分;两组患者治疗前后血清炎症因子水平;两组腹痛、腹胀及发热症状好转时间。结果治疗前,两组患者腹水渗出液细胞成分(白细胞、多核细胞)比较,差异无统计学意义(P>0.05);研究组治疗后腹水渗出液细胞成分(白细胞、多核细胞)水平低于对照组,差异具有统计学意义(P<0.05);两组患者治疗前血清炎症因子水平(白细胞、C反应蛋白)比较,差异无统计学意义(P>0.05);研究组治疗后血清炎症因子水平(白细胞、C反应蛋白)水平低于对照组,差异具有统计学意义(P<0.05);研究组腹痛、腹胀及发热症状好转时间均短于对照组,差异具有统计学意义(P<0.05)。结论相对于利奈唑胺,万古霉素治疗耐甲氧西林金黄色葡萄球菌所致腹膜透析相关性腹膜炎的疗效肯定,减轻体内炎症程度及改善腹部症状。 Objective To investigate the difference of therapeutic effect of different drugs on peritoneal dialysis-related peritonitis caused by methicillin-resistant Staphylococcus aureus. Methods Patients with peritoneal dialysis-related peritonitis caused by methicillin-resistant Staphylococcus aureus in our hospital were divided into study group(treated with vancomycin) and control group(treated with linezolid). The cellular components of ascites exudate before and after treatment, the levels of serum inflammatory factors before and after treatment, and the improvement time of abdominal pain, abdominal distension and fever in the two groups were compared. Results Before treatment, there was no significant difference in ascites exudate cell components(white blood cells, polynuclear cells) between the two groups(P > 0.05). After treatment, the level of ascites exudate cell components(white blood cells, polynuclear cells) in the study group was lower than that in the control group, and the difference was statistically significant(P < 0.05). There was no significant difference in serum inflammatory factors(leucocyte, C-reactive protein) between the two groups before treatment(P > 0.05). The levels of serum inflammatory factors(leucocyte and C-reactive protein) in the study group were lower than those in the control group after treatment, and the difference was statistically significant(P < 0.05). The improvement time of abdominal pain, abdominal distension and fever in the study group was shorter than that in the control group, and the difference was statistically significant(P < 0.05). Conclusion Compared with linezolid, vancomycin is effective in the treatment of peritoneal dialysis-related peritonitis caused by methicillin-resistant Staphylococcus aureus, reducing the degree of inflammation in vivo and improving abdominal symptoms.
作者 耿玉玲 GENG Yuling(Department of Renal Medicine, Shijingshan Hospital, Beijing 100043, China)
出处 《中国继续医学教育》 2019年第17期113-115,共3页 China Continuing Medical Education
关键词 MRSA 腹膜透析 腹膜炎 万古霉素 利奈唑胺 炎症 MRSA peritoneal dialysis peritonitis vancomycin linezolid inflammation
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