Objective:To explore the predictive effect of serum placental growth factor(PLGF)and pregnancy-associated protein(PAPP-A)combined with B ultrasound on pre-eclampsia in early and middle pregnancy.Methods:A retrospective analysis was made of the clinical data of 38 women diagnosed as pre-eclampsia in the early and middle trimester of pregnancy(11-13+6 weeks of pregnancy)who underwent obstetrics and gynecology examination in our hospital from April 2018 to December 2018,who were noted as disease group.In addition,the clinical data of 462 women with no pre-eclampsia in the early and middle trimester of pregnancy(11-13+6 weeks of gestation)who were registered in obstetrics and Gynecology Department of our hospital during the same period were analyzed retrospectively,who were noted as healthy group.The 2 groups were examined by PLGF,PAPP-A and B ultrasound in the early and middle pregnancy.The levels of PLGF and PAPP-A in serum and the results of B ultrasound(PI,RI and S/D indexes of uterine artery)were compared between the two groups.The ROC curve was used to analyze the predictive value of serum PLGF,PAPP-A combined with B ultrasound in pre-eclampsia Results:The serum PLGF level in the disease group was significantly lower than that in the healthy group(P<0.05).The level of PAPP-A was significantly higher than that in healthy group(P<0.05).The PI,RI and S/D of the uterine artery in the disease group were significantly higher than those in the healthy group(P<0.05).The sensitivity,specificity and AUC of serum PLGF,PAPP-A combined with B ultrasound in predicting pre-eclampsia were 89.47%,98.48%and 0.897 respectively,which were higher than those of serum PLGF,PAPP-A,PI,RI and S/D respectively.Conclusion:The levels of PLGF and PAPP-A in serum of pre-eclampsia patients decreased significantly in early and middle pregnancy,and the levels of PI,RI and S/D in uterine artery also increased abnormally.The detection of PLGF and PAPP-A in serum combined with B ultrasound has a good predictive value for pre-eclampsia.
Chinese Journal of Birth Health & Heredity
Early and middle pregnancy
Placenta growth factor
Pregnancy associated protein