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孕早中期血清PLGF、PAPP-A检测联合B超对子痫前期的预测分析

Prediction of pre-eclampsia by combined detection of serum PLGF,PAPP-A and B ultrasound in early and mid pregnancy
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摘要 目的探讨孕早中期血清胎盘生长因子(PLGF)、妊娠相关蛋白(PAPP-A)检测联合B超检查对子痫前期的预测作用。方法回顾性分析2018年4月~2018年12月在我院妇产科建档产检、且跟踪随访确诊为子痫前期的38例孕早中期(孕11~孕13+6w)妇女的临床资料,记为疾病组;另回顾性分析同时间段在我院妇产科建档产检、且跟踪随访未发生子痫前期的462例孕早中期(孕11~孕13+6w)妇女的临床资料,记为健康组。2组均于孕早中期进行PLGF、PAPP-A检测和B超检查。对比2组血清PLGF、PAPP-A水平、B超检查结果(子宫动脉PI、RI及S/D指标)。采用ROC曲线分析血清PLGF、PAPP-A联合B超检查指标对子痫前期的预测价值。结果疾病组血清PLGF水平明显低于健康组(P<0.05),PAPP-A水平明显高于健康组(P<0.05);疾病组子宫动脉PI、RI及S/D均明显高于健康组(P<0.05);血清PLGF、PAPP-A水平联合B超检查对子痫前期预测的灵敏度、特异度和AUC分别为89.47%、98.48%和0.897,均分别高于血清PLGF、PAPP-A、PI、RI及S/D检查。结论子痫前期患者孕早中期血清PLGF水平显著降低,PAPP-A水平明显升高,子宫动脉PI、RI及S/D也异常升高,血清PLGF、PAPP-A检测联合B超检查对子痫前期有良好的预测价值。 Objective:To explore the predictive effect of serum placental growth factor(PLGF)and pregnancy-associated protein(PAPP-A)combined with B ultrasound on pre-eclampsia in early and middle pregnancy.Methods:A retrospective analysis was made of the clinical data of 38 women diagnosed as pre-eclampsia in the early and middle trimester of pregnancy(11-13+6 weeks of pregnancy)who underwent obstetrics and gynecology examination in our hospital from April 2018 to December 2018,who were noted as disease group.In addition,the clinical data of 462 women with no pre-eclampsia in the early and middle trimester of pregnancy(11-13+6 weeks of gestation)who were registered in obstetrics and Gynecology Department of our hospital during the same period were analyzed retrospectively,who were noted as healthy group.The 2 groups were examined by PLGF,PAPP-A and B ultrasound in the early and middle pregnancy.The levels of PLGF and PAPP-A in serum and the results of B ultrasound(PI,RI and S/D indexes of uterine artery)were compared between the two groups.The ROC curve was used to analyze the predictive value of serum PLGF,PAPP-A combined with B ultrasound in pre-eclampsia Results:The serum PLGF level in the disease group was significantly lower than that in the healthy group(P<0.05).The level of PAPP-A was significantly higher than that in healthy group(P<0.05).The PI,RI and S/D of the uterine artery in the disease group were significantly higher than those in the healthy group(P<0.05).The sensitivity,specificity and AUC of serum PLGF,PAPP-A combined with B ultrasound in predicting pre-eclampsia were 89.47%,98.48%and 0.897 respectively,which were higher than those of serum PLGF,PAPP-A,PI,RI and S/D respectively.Conclusion:The levels of PLGF and PAPP-A in serum of pre-eclampsia patients decreased significantly in early and middle pregnancy,and the levels of PI,RI and S/D in uterine artery also increased abnormally.The detection of PLGF and PAPP-A in serum combined with B ultrasound has a good predictive value for pre-eclampsia.
作者 刘晓宁 潘晓华 申彩霞 LIU Xiao-ning;PAN Xiao-hua;SHEN Cai-xia(Department of Obstetrics and Gynecology,Qingdao Womenand Children's Hospital,Qingdao 266000,China)
出处 《中国优生与遗传杂志》 2019年第5期566-568,555共4页 Chinese Journal of Birth Health & Heredity
关键词 孕早中期 胎盘生长因子 妊娠相关蛋白 B超 子痫前期 Early and middle pregnancy Placenta growth factor Pregnancy associated protein B ultrasound Preeclampsia
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