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甲强龙合用复方磺胺甲噁唑对中重度缺氧艾滋病患者伴肺孢子菌肺炎的临床效果分析 预览

Clinical effect of methylprednisolone combined with compound sulfamethoxazole on moderate to severe hypoxic AIDS patients with Pneumocystis pneumonia
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摘要 目的分析研究对中重度缺氧艾滋病患者伴肺孢子菌肺炎给予甲强龙合用复方磺胺甲噁唑的疗效。方法选择2014年1月~2017年12月我院收治的中重度缺氧艾滋病患者伴肺孢子菌肺炎共32例,随机分为对照组和试验组,各16例,对照组给予常规复方磺胺甲噁唑治疗,试验组在对照组基础上给予甲强龙治疗,对比两组患者伴肺孢子菌肺炎患者治疗临床效果、治疗后PaO2、SaO2、PaCO2及不良反应。结果试验组患者的治疗总有效率87.50%明显高于对照组患者56.25%(χ^2=3.865,P<0.05),治疗1周后,试验组患者PaO2(68.54±7.96)mmHg、SaO2(91.67±3.64)%高于对照组,PaCO2(26.05±3.17)mmHg低于对照组(t=2.929,2.272,5.087,P<0.05);治疗2周后,试验组患者PaO2(79.98±10.99)mmHg、SaO2(94.78±3.98)%高于对照组,PaCO2(20.11±3.21)mmHg低于对照组(P<0.05)(t=2.440,2.609,6.402,P<0.05),两组不良反应对比无显著差异(χ^2=0.237,P>0.05)。结论中重度缺氧艾滋病患者伴肺孢子菌肺炎给予甲强龙合用复方磺胺甲噁唑的疗效显著,可改善患者缺氧状态,安全性较高,值得应用。 Objective To study the efficacy of methylprednisolone combined with compound sulfamethoxazole in moderate to severe hypoxic AIDS patients with Pneumocystis pneumonia.Methods Thirtytwo moderate to severe hypoxic AIDS patients with Pneumocystis pneumonia were selected from January 2014 to December 2017 in our hospital.They were randomly divided into control group and experimental group,16 cases in each group.The control group was treated with routine compound sulfamethoxazole and the experimental group was treated with methylprednisolone on the basis of the control group.The therapeutic effects,PaO2,SaO2,PaCO2 and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 87.50% higher than 56.25% in the control group (χ^2=3.865,P<0.05),After one week of treatment,PaO2 (68.54±7.96) mmHg and SaO2 (91.67±3.64)% in the experimental group were higher than those in the control group,while PaCO2 (26.05±3.17) mmHg was lower than those in the control group (t=2.929,2.272,5.087,P <0.05).PaO2 (79.98±10.99) mmHg,SaO2 (94.78±3.98)% higher than that in the control group,PaCO2 (20.11±3.21) mmHg lower than that in the control group (P<0.05)(t=2.440,2.609,6.402,P<0.05),and there was no significant difference in adverse reactions between the two groups (χ^2=0.237,P>0.05).Conclusion Medromethylprednis olone combined with compound sulfamethoxazole is effective in moderate to severe hypoxic AIDS patients with Pneumocystis pneumonia,and can improve the hypoxic status of patients with high safety,which is worthy of application.
作者 代振柳 DAI Zhen-liu(Department of medicine,Rongan County People's Hospital,Guangxi Liuzhou 545400,China)
出处 《临床医药文献电子杂志》 2019年第42期4-6,共3页 Journal of Clinicl Medical Literature ( Electronic Edition )
关键词 甲强龙 复方磺胺甲噁唑 艾滋病 肺孢子菌肺炎 临床疗效 不良反应 Methylprednisolone Compound sulfamethoxazole AIDS Pneumocystis pneumonia Clinical efficacy adverse reactions
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