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阿片类药物镇痛效果影响因素的研究进展 预览 被引量:1

Advances in research on factors influencing the analgesic effect of opioids
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摘要 阿片类药物是目前应用最广泛的镇痛药,其镇痛效果在个体之间存在广泛差异,造成这些差异的因素有很多,其中遗传因素占有重要的地位,药物代谢酶、转运蛋白、受体和药物作用靶点的基因多态性特别是基因的单核苷酸多态性(SNP)是引起阿片类药物效应和副作用个体差异的重要原因。此外,还包括年龄、性别、肝病肾病、肥胖等因素对其镇痛效果也会产生一定的影响,本文对关于这些影响因素的研究进行综述,从而指导临床阿片类药物的用药。 Opioids are the most widely used analgesic drugs at present, and their analgesic effects wary widely among individuals. There are many factors that can cause these differences, among which genetic factors play an important role. Drug metabolism enzymes, transporters, receptors, and genetic polymorphisms of drug targets in particular gene single nucleotide polymorphisms (SNPs) are also important causes of individual differences in opioid drug effects and side effects. In addition, age, gender, liver disease, kidney disease, obesity and other factors may also have a certain impact on the analgesic effects. This article reviews the research on these influencing factors to guide the clinical use of opioiods.
作者 马会芹 占乐云 许晴雯 MA Huiqin;ZHAN Leyun;XU Qingwen(Department of Anesthesiology,The People’s Hospital of China Three Gorges University,Yichang 443000,China)
出处 《麻醉安全与质控》 2019年第3期172-176,共5页 Perioperative Safety and Quality Assurance
基金 宜昌市医学拔尖人才培养工程(2017年).
关键词 阿片类药物 镇痛 基因多态性 年龄 性别 肥胖 opioids analgesia genetic polymorphism age gender obesity
作者简介 马会芹,硕士研究生, E-mail: 297186050@qq.com;通信作者:占乐云, E-mail: Leyunzhan@163.com.
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