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托拉塞米治疗急性心力衰竭的临床疗效分析 预览

Analysis of the Clinical Efficacy of Toracemide in the Treatment of Acute Heart Failure
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摘要 目的:探究托拉塞米治疗急性心力衰竭的临床疗效及安全性。方法:收集2015年7月-2018年3月本院救治的320例急性心力衰竭患者视为研究对象,按随机数表方式分为对照组(呋塞米)、研究组(托拉塞米)。比较两组治疗前后心率、脑钠肽(BNP)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、临床疗效及不良反应。结果:治疗后,研究组心率、BNP水平明显低于对照组(P<0.05);组间治疗后比较,研究组LVEDD、LVESD明显低于对照组,LVEF高于对照组,差异显著(P<0.05);研究组总有效率与对照组比较差异显著(P<0.05);两组不良反应发生率对比有统计学意义(P<0.05)。结论:托拉塞米治疗急性心力衰竭的疗效显著,能显著改善心功能状况,降低心率与脑钠肽,安全性高,值得临床应用。 Objective: To explore the clinical efficacy and safety of toracemide in the treatment of acute heart failure. Methods: 320 patients with acute heart failure treated in our hospital from July 2015 to March 2018 were collected as the study subjects, and divided into the control group (furosemide) and the study group (toracemide) according to the random number table. Heart rate, cerebral natriuretic peptide (BNP), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), clinical efficacy and adverse reactions were compared between the two groups before and after treatment. Results: After treatment, heart rate and BNP levels in the study group were significantly lower than those in the control group ( P < 0.05 ). After treatment, LVEDD and LVESD in the study group were significantly lower than those in the control group, and LVEF in the study group was significantly higher than that in the control group ( P <0.05). The total effective rate of the study group was significantly different from that of the control group( P <0.05). The incidence of adverse reactions between the two groups was statistically significant ( P <0.05). Conclusion: Toracemide is effective in the treatment of acute heart failure, can significantly improve cardiac function, reduce heart rate and brain natriuretic peptide, high safety, worthy of clinical application.
作者 刘光艳 Liu Guangyan(Cardiac Monitoring Ward, Qilu Hospital of Shandong University,Jinan Shandong,250012,China)
出处 《黑龙江医药》 CAS 2019年第3期569-571,共3页 Heilongjiang Medicine journal
关键词 托拉塞米 急性心力衰竭 临床疗效 安全性 Tolasemi Acute heart failure Clinical efficacy security
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