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CLCA4基因在头颈部鳞状细胞癌中的表达与其临床意义 预览

Expression and clinical significance of CLCA4 gene in head and neck squamous cell carcinoma
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摘要 目的探讨CLCA4基因在头颈部鳞状细胞癌中的表达与其临床意义。方法利用癌症和肿瘤基因图谱(TCGA)数据库,基于生物信息学检测CLCA4在头颈部鳞状细胞癌中的表达情况,通过分析网站中TCGA数据库的552例头颈部鳞状细胞癌患者(时间截止至2018年10月),绘制头颈部鳞状细胞癌中CLCA4在各种条件下的箱式图。并通过生存曲线、蛋白-蛋白相互作用网络(PPI)、基因本体(GO)和京都基因与基因组百科全书(KEGG)分析探讨CLCA4基因差异表达在头颈部鳞状细胞癌对患者产生的影响与重要性和判定差异基因主要影响的生物学功能或者通路。结果 CLCA4在头颈部鳞状细胞癌中表达显著下调(P<0.05),同时,CLCA4的低表达和较差的预后相关(P=0.01883)。PPI、GO和KEGG分析结果显示,CLCA4除了参与离子通道与表皮发育等调控,还发现其与免疫、炎性反应相关。结论 CLCA4在头颈部鳞状细胞癌参与免疫调节作用,提示头颈部鳞状细胞癌的免疫异常可能是影响患者生存率的关键,同时为头颈部鳞状细胞癌提供了全新的研究方向与思路。 Objective To investigate the expression and clinical significance of CLCA4 gene in head and neck squamous cell carcinoma. Methods The expression of CLCA4 in head and neck squamous cell carcinoma was detected by using TCGA database based on bioinformatics. A box diagram of CLCA4 in head and neck squamous cell carcinoma under various conditions was drawn by analyzing 552 head and neck squamous cell carcinoma patients (up to October 2018) in the cancer genome atlas (TCGA) database of website. The effects and importance of CLCA4 gene differential expression on patients with head and neck squamous cell carcinoma and the biological function or pathway of determining the main effects of different genes were discussed by survival curve,protein-protein interaction network (PPI),gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG). Results The expression of CLCA4 was significantly down-regulated in head and neck squamous cell carcinomas,and the low expression of CLCA4 was associated with poor prognosis (P=0.01883). The results of PPI,GO and KEGG analysis showed that CLCA4 was not only involved in the regulation of ion channels and epidermal development,but also related to immune and inflammatory responses. Conclusion CLCA4 participates in the immunoregulation in head and neck squamous cell carcinoma,suggesting that the immune abnormality of head and neck squamous cell carcinoma may be the key factor affecting the survival rate of patients,and provides a new research direction and ideas for head and neck squamous cell carcinoma.
作者 张永红 刘雅丽 ZHANG Yong-hong;LIU Ya-li(Department of Otolaryngology-Head and Neck Surgery,Xiangyang No.1 People′s Hospital Affiliated to Hubei Medical College,Xiangyang 441000,China)
出处 《中国当代医药》 2019年第14期17-20,F0004共5页 China Modern Medicine
关键词 CLCA4 癌症和肿瘤基因图谱 头颈部鳞状细胞癌 免疫 炎性 大数据 CLCA4 The cancer genome atlas Head and neck squamous cell carcinoma Immunity Inflammation Big data
作者简介 张永红(1976-),女,本科,主管护师,主要从事护理管理和耳鼻咽喉头颈外科临床护理工作;通讯作者:刘雅丽(1992-),女,硕士,研究方向:耳鼻喉头颈肿瘤的发生、发展及治疗预后相关.
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