Objective: To compare the clinical effects of anticoagulation and double antithrombotic therapy in the treatment of high risk coronary heart disease complicated with atrial fibrillation. Methods: 138 cases of high risk coronary heart disease patients with atrial fibrillation were selected and randomly divided into control group (double antithrombotic therapy) and observation group (anticoagulation treatment),with 69 cases in each group. The clinical efficacy of the two groups was compared. Results: After 3 years of follow-up, compared with the control group, the use of proton pump inhibitors and the incidence of major end-point events were significantly decreased in the observation group ( P < 0.05). However, there was no significant difference between groups in the incidence of bleeding events and secondary endpoint events ( P >0.05). There was no significant difference in embolism risk score (CHADS2) between the observation group and the control group ( P >0.05), but the patients in the observation group were higher than those in the control group ( P < 0.05). Conclusion: Anticoagulation therapy is effective in patients with high risk coronary heart disease complicated with atrial fibrillation, which is beneficial to reduce the risk of embolism, but it is necessary to control the risk of bleeding during the treatment.
Journal of Mathematical Medicine
high-risk coronary heart disease