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炎性小体与肺部疾病发生及其干预的研究进展

Advances in inflammasome and pulmonary disease and its intervention
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摘要 核苷酸结合寡聚结构域(NOD)样受体家族(NLRs)能识别微生物的保守序列并启动炎性反应,NOD样受体蛋白3(NLRP3)是NLRs家族最具代表性的成员之一。受多种内源性或外源性危险信号激活后,NLRP3与凋亡相关微粒蛋白(ASC)和半胱氨酸天冬氨酸特异性蛋白酶-1(Caspase-1)组合成炎性小体,作用于下游白细胞介素-1β(IL-1β)、白细胞介素-18(IL-18)等炎性因子,促进其成熟和分泌,同时可与消皮素D(GSDMD)相互作用,最终导致细胞炎性坏死。NLRP3与肺部疾病的发生发展均密切相关。寻找NLRP3炎性通路上关键蛋白的抑制剂可能为治疗相关疾病提供新途径和新方法。现就NLRP3炎性小体的组成、其与肺部疾病发生的关系及其干预的研究进展进行综述。 Nucleotide-binding oligomerization domain like receptors (NLRs) can recognize conserved sequences of microorganisms and initiate inflammation, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) is one of the most representative members of the NLRs family.Activated by a variety of endogenous or exogenous dangerous signals, NLRP3 combines with apoptosis-associated speck-like protein(ASC) and caspase-1 to form inflammasome.And then it acts on downstream inflammatory factors such as inter-leukin-1β(IL-1β) and interleukin-18 (IL-18) to promote their maturation and secretion.At the same time, it can interact with gasdermin D(GSDMD)and eventually lead to pyroptosis.It was found that, NLRP3 was closely related to the occurrence and development of pulmonary diseases.Finding inhibitors of key proteins in NLRP3 inflammasome pathway may provide a new way to treat related diseases.This article reviews the composition of NLRP3 inflammasome, the relationship between NLRP3 inflammasome and the occurrence of pulmonary diseases, and the advances in intervention research.
作者 张慧珊 叶乐平 Zhang Huishan;Ye Leping(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China;Department of Pediatric Respiratory, the Second Affiliated Hospital and Yuying Children′s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China)
出处 《中华实用儿科临床杂志》 CSCD 北大核心 2019年第9期711-714,共4页 Journal of Applied Clinical Pediatrics
基金 国家自然科学基金(81771635).
关键词 炎性小体 肺部疾病 炎性反应 细胞焦亡 抑制剂 Inflammasome Pulmonary diseases Inflammation Pyroptosis Inhibitor
作者简介 通信作者:叶乐平,Email:yeleping@163.com.
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