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碱性成纤维细胞生长因子与孤独症谱系障碍的关联

Association between basic fibroblast growth factor and autism spectrum disorders
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摘要 目的了解孤独症患儿血液中碱性成纤维细胞生长因子(FGF2)水平及其与行为表现的关联性,为孤独症的病因研究提供证据。方法收集2015年9月至2017年9月在哈尔滨医科大学儿童发育行为研究中心及黑龙江省残疾人孤独症定点康复机构进行康复训练的ASD患儿40名作为病例组,哈尔滨幼儿园41名健康儿童为对照组,应用酶联免疫吸附试验(ELISA)方法检测血浆中FGF2水平。采用儿童孤独症行为量表(ABC)、儿童孤独症评定量表(CARS)、皮博迪图片词汇测验(PPVT)等量表评估孤独症患儿的严重程度及智力水平。结果 ASD患儿血液中FGF2水平(4.95 pg/mL)与正常儿童(8.51 pg/mL)差异无统计学意义(P>0.05),但在4岁年龄组中,ASD患儿(1.99 pg/mL)与对照儿童(6.82 pg/mL)的FGF2水平差异有统计学意义(P<0.05)。不同严重程度ASD患儿的FGF2水平差异有统计学意义(P<0.05);不同智商水平的ASD患儿体内FGF2水平差异有统计学意义(P<0.05)。结论孤独症患儿的FGF2水平可能存在异常,且与孤独症的严重程度及智力水平存在关联性。 Objective To investigate the level of human blood basic fibroblast growth factor(FGF2) among children with autism spectrum disorder(ASD) and its correlation with behavioral phenotypes, to provide a reference for etiological research of ASD. Methods ASD Children were selected to get rehabitation training in reseach center of children development behavior in Harbin Medical University and the rehabitation constitution for ASD disabilities in Heilongjiang, 40 children were induded as ASD group, 41 healthy children in Harbin kindergarten was classified as control group. The Autism Behavior Checklist(ABC), Childhood Autism Rating Scale(CARS) and Peabody Picture Vocabulary Test(PPVT) were used to assess the severity and intelligence of ASD children, respectively. Results No difference was found in FGF2 level between ASD children(4.95 pg/mL) and normal children(8.51 pg/mL)(P>0.05). However, difference in FGF2 level between the two groups were found in 4-year-old group(P<0.05). The level of FGF2 differed across different severity and intelligence of ASD children(P<0.05). Conclusion Abnormal levels of FGF2 in ASD children may correlate with severity of autistic traits and intelligence of children.
作者 杨晓蕾 邹明扬 王琳 马永娟 韩盼盼 武丽杰 Xiaolei;ZOU Mingyang;WANGLin;MA Yongjuan;HAN Panpan;WU Lijie(School of Public Health, Qiqihar Medical College, Qiqihar(161000), Heilongjiang Province, China)
出处 《中国学校卫生》 CAS 北大核心 2019年第4期507-510,共4页 Chinese Journal of School Health
基金 黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2018036).
关键词 成纤维细胞生长因子2 孤独性障碍 病例对照研究 儿童 酶联免疫吸附测定 Fibroblast growth factors 2 Autistic disorder Case-control studies Child Enzyme-linked immunosorbent assay
作者简介 杨晓蕾(1985-),女,黑龙江齐齐哈尔人,博士,讲师.主要研究方向为流行病及儿少卫生学;通讯作者:武丽杰,E-mail:wulijiehyd@126.com.
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