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血浆miRNA-126表达与妊娠期高血压疾病的相关性分析 预览

Correlation analysis of the expression of plasma miRNA-126 and hypertensive disorder complicating pregnancy
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摘要 目的研究血浆miRNA-126表达与妊娠期高血压疾病的相关性。方法选取2015年2月~2018年2月四川省泸州市人民医院诊治的妊娠高血压疾病患者93例作为研究对象,并将其按照疾病进行分组。其中妊娠期高血压组30例,轻度子痫前期组29例,重度子痫前期组34例。另取同期体检的健康妊娠妇女20名作为对照组。分别采用逆转录-聚合酶链式反应(RT-PCR)技术检测各组研究对象的血浆miRNA-126表达情况;同时比较各组收缩压、舒张压、24 h蛋白尿水平,并将其与miRNA-126表达进行相关性分析。结果与对照组比较,妊娠期高血压组血浆miRNA-126表达下调,而轻度子痫前期组血浆miRNA-126表达低于妊娠期高血压组,重度子痫前期组血浆miRNA-126表达低于轻度子痫前期组,差异均有统计学意义(P <0.05)。妊娠期高血压组收缩压、24 h蛋白尿水平均明显高于对照组;轻度子痫前期组收缩压、24 h蛋白尿水平高于妊娠期高血压组;重度子痫前期组收缩压、24 h蛋白尿水平高于轻度子痫前期组;对照组舒张压水平低于妊娠期高血压组、轻度子痫前期组、重度子痫前期组,差异均有统计学意义(P <0.05)。经Spearman相关性分析,妊娠期高血压疾病患者miRNA-126基因表达与其收缩压、舒张压、24 h蛋白尿水平均呈负相关(r=-0.583、-0.626、-0.611、均P <0.05)。结论妊娠期高血压疾病患者血浆miRNA-126表达明显下调,且随着病情的逐渐加重,血浆miRNA-126表达下调越明显。血浆miRNA-126表达下调可能在妊娠期高血压疾病的发生、发展过程中发挥着至关重要的作用。 Objective To study the relationship between the expression of plasma miRNA-126 and hypertensive disorder complicating pregnancy. Methods A total of 93 patients with hypertensive disorder complicating pregnancy admitted in Luzhou People′s Hospital of Sichuan Province from February 2015 to February 2018 were selected as the study subjects and grouped according to their diseases. There were 30 cases in pregnancy hypertension group, 29 cases in mild preeclampsia group and 34 cases in severe preeclampsia group. Another 20 healthy pregnant women who underwent physical examination during the same period were taken as control group. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of plasma miRNA-126 of each group, and the levels of systolic blood pressure, diastolic blood pressure and 24-hour proteinuria level were compared, and the correlation between them and the expression of plasma miRNA-126 were analyzed. Results Compared with the control group, the expression of plasma miRNA-126 was down-regulated in the pregnancy hypertension group, while the expression of plasma miRNA-126 in the mild preeclampsia group was lower than that in the pregnancy hypertension group, and the miRNA-126 expression in the severe preeclampsia group was lower than that in the mild preeclampsia group, the difference were statistically significant (P < 0.05). The systolic blood pressure and 24-hour proteinuria level in pregnancy hypertension group were significantly higher than those in control group;the systolic blood pressure and 24-hour proteinuria level in mild preeclampsia group were higher than those in pregnancy hypertension group;the systolic blood pressure and 24-hour proteinuria level in severe preeclampsia group were higher than those in mild preeclampsia group;the diastolic blood pressure levels in control group were lower than those in pregnancy hypertension group, mild preeclampsia group, severe preeclampsia group, the differences were statistically significant (all P < 0.05). According
作者 何晓焱 彭诗寒 赵磊 罗玉萍 刘霞 HE Xiaoyan;PENG Shihan;ZHAO Lei;LUO Yuping;LIU Xia(Department of Obstetrics and Gynecology, Luzhou People′s Hospital, Sichuan Province, Luzhou 646000, China;Department of Obstetrics and Gynecology, Sichuan Provincial People′s Hospital, Sichuan Province, Chengdu 610072, China)
出处 《中国医药导报》 CAS 2019年第8期76-79,共4页 China Medical Herald
基金 四川省泸州市科技计划项目[2015-S-49(2/3)]。
关键词 妊娠期高血压疾病 miRNA-126 血浆 轻度子痫前期 重度子痫前期 Hypertensive disorder complicating pregnancy miRNA-126 Plasma Mild preeclampsia Severe preeclampsia
作者简介 何晓焱(1975.10-),女,副主任医师;研究方向:妊娠高血压。
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