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补肾活血方联合戈舍瑞林治疗子宫内膜异位症的临床观察

Clinical Observation of Strengthening Kidney and Activating Blood Decoction Combined with Goserelin in Treatment of Patients with Endometriosis
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摘要 目的:探究补肾活血方联合戈舍瑞林治疗子宫内膜异位症的临床效果。方法:选取2016年3月-2017年8月于医院接受治疗的子宫内膜异位症患者100例,并按数字表法随机分为对照组50例与观察组50例。予以对照组戈舍瑞林进行治疗,观察组则采用补肾活血方联合戈舍瑞林治疗。分析两组症状总评分、妊娠情况、激素水平、排卵恢复时间、月经恢复时间、临床效果及不良反应。结果:经过治疗后,观察组疼痛(1.61±0.33)分、经血夹块(1.34±0.40)分、盆腔包块(2.17±0.64)分、腰膝酸软(1.24±0.22)分症状评分明显低于对照组疼痛(2.59±0.58)分、经血夹块(2.17±0.67)分、盆腔包块(2.74±0.50)分、腰膝酸软(1.75±0.33)分症状评分;观察组总妊娠率(70.83%)明显高于对照组(40.91%);观察组FSH(4.25±1.14)U/L、E2(63.25±14.37)μmol/L、LH(5.35±1.41)U/L明显低于对照组FSH(5.31±1.44)U/L、E2(92.51±20.46)μmol/L、LH(6.18±1.55)U/L;观察组排卵恢复时间(10.56±2.71)d、月经恢复时间(25.11±4.52)d均明显少于对照组排卵恢复时间(18.13±3.17)d、月经恢复时间(31.33±4.28)d;观察组临床总有效率88.00%、不良反应发生率6.00%明显优于对照组临床总有效率72.00%、不良反应发生率22.00%,差异有统计学意义(P<0.05)。结论:子宫内膜异位症患者使用补肾活血方联合戈舍瑞林进行治疗后,其卵巢功能及性激素分泌水平均有显著改善,临床不适症状明显减轻,不良反应发生率下降,整体治疗效果较优。 Objective:To explore the clinical effect of Strengthening Kidney and Activating Blood Decoction combined with goserelin in treatment of the patients with endometriosis.Methods:Totally 100 patients with endometriosis in our hospital from March 2016 to August 2017 were selected and randomly divided into the control group(50 cases)and the observation group(50 cases)according to the digital table method.The control group was given goserelin and the observation group was treated with Strengthening Kidney and Activating Blood Decoction combined with goserelin.The total score of symptoms,pregnancy,hormone level,ovulation recovery time,menstrual recovery time,clinical effect and adverse reaction were analyzed in two groups.Results:After treatment,the scores of pain(1.61±0.33),menstrual blood clips(1.34±0.40),pelvic lump(2.17±0.64),waist and knee soft(1.24±0.22)were significantly lower than the control group’s scores of pain(2.59±0.58),menstrual blood clips(2.17±0.67),pelvic lump(2.74±0.50)and waist and knee soft(1.75±0.33).The total pregnancy rate of the observation group(70.83%)was significantly higher than that of the control group(40.91%).And the observation group’s FSH(4.25±1.14)U/L,E2(63.25±14.37)μmol/L and LH(5.35±1.41)U/L were significantly lower than the control group’s FSH(5.31±1.44)U/L,E2(92.51±20.46)μmol/L and LH(6.18±1.55)U/L.The time of ovulation recovery(10.56±2.71)d and menstrual recovery time(25.11±4.52)d were significantly less than the control group’s time of ovulation recovery(18.13±3.17)d and menstrual recovery time(31.33±4.28)d,and the clinical total effective rate(88%)and the incidence rate of adverse reactions(6%)of the observation group were obviously better than the control group’s total clinical efficiency rate(72%)and the incidence rate of reaction(22%),and the difference was statistically significant(P<0.05).Conclusion:For endometriosis patients,Strengthening Kidney and Activating Blood Decoction combined with goserelin can significantly improve the ovarian functi
作者 徐晓飞 石明晴 章芳芳 XU Xiaofei;SHI Minqing;ZHANG Fangfang(Department of Obstetrics and Gynecology,Lishui Hospital of Traditional Chinese Medicine,Lishui 323000,Zhejiang,China)
出处 《中华中医药学刊》 CAS 北大核心 2019年第2期492-495,共4页 Chinese Archives of Traditional Chinese Medicine
基金 浙江省中医药管理局项目(2017ZB101) 丽水市科技计划项目(2016GYX48).
关键词 子宫内膜异位症 补肾活血方 戈舍瑞林 症状评分 endometriosis Strengthening Kidney and Activating Blood Decoction goserelin symptom score
作者简介 徐晓飞(1975-),女,浙江永康人,副主任医师,学士,研究方向:妇产科疾病研究;通讯作者:石明晴(1981-),女,安徽安庆人,主治医师,硕士,研究方向:不孕症研究。E-mail:936391460@qq.com.
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