Objective To investigate the effect of salidroside on intracerebral hemorrhage (ICH) and to explore the possible mechanism. Methods Seventy-five rats were randomly divided into 5 groups:sham group,ICH group,low dosage treatment group,medium dosage treatment group and high dosage treatment group. After establishing ICH model,rats were received 10mg/kg,20mg/kg or 40mg/kg Salidroside by gavage once a day for 10 days. The neuronal function impairment of rats was scored and the brain water content was measured. The myeloperoxidase (MPO) activity in brain was determined. Moreover,the protein and mRNA expression of hypoxia inducible factor 1α(HIF-1α) and vascular endothelial growth factor (VEGF) in brain hematoma tissues were detected by western blotting and RT-PCR,respectively. Results After Salidroside treatment,the score of neuronal function impairment was lower than ICH rats without treatment.In addition,the brain water content and MPO activity were significantly decreased after Salidroside administration,whereas the protein and mRNA expression of HIF-1αand VEGF in brain hematoma tissues were increased. Conclusion Salidroside can exert protective effects on brain tissues in ICH rats. These effects may be through increasing HIF-1αand VEGF expression in brain hematoma tissues.
Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease
hypoxia inducible factor-1α
vascular endothelial growth factor
neurological deficit score
brain water content