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复方红景天滴丸的制备工艺研究 预览

Study on the preparation process of compound Rhodiola crenulata dropping pill
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摘要 [目的]筛选、优化复方红景天的最佳提取工艺,初步探索该方的滴丸制备方法。[方法]采用正交实验法,以红景天苷含量及干膏收率为考察指标,对提取时间、乙醇浓度、提取次数、溶剂倍数4个因素进行优化选择。考察冷凝剂、基质的筛选与配比、药物与基质比例,优化成型工艺。[结果]实结果表明提取时间、提取次数、溶剂倍数对制备工艺有显著性影响。最佳提取工艺条件为10倍量,浓度为60%的乙醇,回流提取2次,每次1.5h。验证实验中红景天苷平均含量为1.73%,RSD=1.2%,测得干膏收率平均值24.82%,RSD=1.6%(n=3)。滴丸制备选取二甲基硅油作为冷凝剂,PEG4000与PEG6000的最佳比例为2:1,药基比例1颐2.5。[结论]优选的复方红景天提取及成型工艺合理、稳定、可行。 [Objective]To screen and optimize the best extraction technology of compound Rhodiola.The preparation method of dropping pills of this prescription is preliminarily explored.[Methods]The process was designed by orthogonal experimental method.Taking the content of salidroside and recovery rate of dry ointment as indexes to optimize 4 factors which includes extraction time,ethanol concentration,extraction times and solvent multiple.Studying condensing agent,matrix and its ratio,drugs and matrix proportion and optimize the molding process.[Results]The results of variance analysis showed that the extraction time,extraction times and solvent multiple had significant impact on the preparation.The optimum extraction process was adding 10 fold amount of 60% ethanol,extracting for 1.5h and 2 times.The average content of salidroside in the test was 1.73%,RSD=1.2% and the yield of dry extract was 24.28%,RSD=1.6%(n=3).Dimethyl siliconeoil was selected as condensing agent.The best ratio of PEG4000 and PEG6000 was 2:1.The ratio of drug to matrix was 1∶2.5.[Conclusion]The extracting and molding process of the optimized compound Rhodiola is reasonable,stable and feasible.
作者 郑路静 刘庆焕 陶遵威 ZHENG Lujing;LIU Qinghuan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Institute of Medical and Pharmaceutical Sciences,Tianjin 300020,China)
出处 《天津中医药大学学报》 CAS 2019年第1期84-87,共4页 Journal of Tianjin University of Traditonal Chinese Medicine
基金 天津市应用基础与前沿技术研究计划(一般项目)(14JCYBJC28700)。
关键词 复方红景天 正交实验 红景天苷 提取工艺 Compound Rhodiola orthogonal test salidroside extraction technology
作者简介 郑路静(1987-),女,硕士研究生,主要研究方向为中药制剂;通讯作者:陶遵威,E-mail:taozunweitj@163.com。
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