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氧化铁纳米粒子在骨组织修复再生中的研究与应用 预览

Application and research of iron oxide nanoparticles in bone tissue repair
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摘要 背景:氧化铁纳米粒子是一种磁性纳米材料,具有优良的特性,使其在医学上的应用越来越广泛,尤其在骨组织再生修复方面起到了积极作用。目的:综述氧化铁纳米粒子在骨组织修复再生中的研究进展及应用。方法:应用计算机检索中国生物医学文献数据库、CNKI数据库、PubMed数据库及Elsevier数据库中发表的相关文献,检索词为“骨修复,骨再生,氧化铁纳米粒子,磁性纳米粒子;IONPs,bone repair,bone regenerate,iron oxide nanoparticles,osteogenesis,stem cell”,查阅2004年5月至2018年1月期间收录的氧化铁纳米粒子在骨组织再生医学方面的相关文章。结果与结论:近年来,磁性纳米粒子在医学研究中得到了广泛应用,例如靶向给药、磁共振成像(MRI)、局部组织热疗和肿瘤治疗、生物分离和生物传感等,目前较为常用的磁性纳米粒子是氧化铁纳米粒子。研究已证明氧化铁纳米粒子与干细胞归巢有密切关系,并且能够携带药物进入特定的靶向部位及促进骨组织再生修复。虽然氧化铁纳米粒子促进骨组织修复研究取得了初步成效,但对于其促进骨愈合机制尚未完全阐明,大部分研究仅局限于基础研究,未来还需加强关于氧化铁纳米粒子促进骨组织愈合通路机制的研究及临床研究。 BACKGROUND: Iron oxide nanoparticles are a kind of magnetic nanomaterial. Their excellent characteristics make them more and more widely used in medicine, especially in bone tissue regeneration and repair. OBJECTIVE: To review the research progress and application of iron oxide nanoparticles in bone tissue repair and regeneration.METHODS: A computer-based search of CBM, CNKI, PubMed and Elsevier was performed for retrieving articles concerning iron oxide nanoparticles for bone tissue regeneration published from May 2004 to January 2018. The keywords were “bone repair;bone regeneration;iron oxide nanoparticles;magnetic nanoparticles” in Chinese and “IONPs;bone repair;bone regenerate;iron oxide nanoparticles;osteogenesis;stem cell” in English. RESULTS AND CONCLUSION: In recent years, magnetic nanoparticles have been widely used in medical research, such as targeted drug delivery, magnetic resonance imaging, local tissue thermotherapy and tumor therapy, biological separation and biological sensors. The magnetic nanoparticles commonly used at present are iron oxide nanoparticles. Studies have proven that iron oxide nanoparticles have a close relationship with stem cell homing, and they are able to carry drugs into a specific target area, promoting bone tissue regeneration and repair. Although initial results have been achieved in the research on iron oxide nanoparticles in promoting bone tissue repair, the mechanism by which iron oxide nanoparticles promote bone healing has not been fully elucidated, and most studies are only limited to basic research. Future basic and clinical studies on the mechanism of iron oxide nanoparticles in promoting bone tissue healing need to be strengthened.
作者 沈梦杰 杨琨 刘琪 Shen Mengjie;Yang Kun;Liu Qi(Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China)
出处 《中国组织工程研究》 CAS 北大核心 2019年第14期2248-2253,共6页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 2017年国家自然科学基金(81760199),项目负责人:杨琨 2018年国家自然科学基金(81860196),项目负责人:刘琪.
关键词 氧化铁纳米粒子 磁性纳米粒子 骨修复 干细胞 成骨 磁性给药 骨再生 纳米粒 四氧化三铁 磁铁矿纳米颗粒 组织工程 Bone Regeneration Nanoparticles Ferrosoferric Oxide Magnetite Nanoparticles Tissue Engineering
作者简介 沈梦杰,女,1990年生,汉族,安徽省阜阳市人,遵义医学院在读硕士,主要从事牙周组织再生研究,ORCID:0000-0002-1600-6357;通讯作者:刘琪,博士,教授,遵义医学院附属口腔医院牙周科,ORCID:0000-0001-8041-6978
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