期刊文献+

妇女宫颈病变筛查分析 预览

Screening Analysis of Cervical Lesions in Women
在线阅读 下载PDF
收藏 分享 导出
摘要 目的研究HPV与宫颈癌及癌前病变的相关性,提供防治宫颈癌的思路。方法以2012年1月~2017年12月送检到浙江迪安诊断技术股份有限公司的433447例宫颈病变标本为研究对象,同时检测人乳头瘤病毒(HPV)基因分型和薄层液基细胞学(TCT),并分析HPV基因亚型分布及年龄分布。结果HPV阳性率为12.51%,其中单一高危HPV阳性率为9.28%,单一低危HPV阳性率为1.22%。HPV亚型阳性率最高的是16型2.09%、58型1.82%、52型1.61%。TCT阳性检出率是5.69%,其中ASC-US3.91%、LSIL1.21%、ASC-H0.32%、HSIL及以上0.23%、AGC0.02%。HPV发病率最高的年龄段是41~50岁,阳性率为5.54%,与其它年龄段比较,差异有统计学意义(P<0.05)。结论HPV亚型中16、52及58感染率最高,同时具有明显年龄特征。HPV感染可引起一系列的宫颈病变,防治重点应针对高危HPV感染的人群。 Objective To study the correlation between HPV and cervical cancer and precancerous lesions,and to provide ideas for the prevention and treatment of cervical cancer.Methods From January 2012 to December 2017,433,447 cases of cervical lesions were sent to Zhejiang Dian Diagnostics Technology Co.,Ltd.for the detection of human papillomavirus(HPV)genotyping and thin-layer liquid-based cells.(TCT),and analysis of HPV gene subtype distribution and age distribution.Results The positive rate of HPV was 12.51%,of which the single high-risk HPV positive rate was 9.28%,and the single low-risk HPV positive rate was 1.22%.The highest positive rates of HPV subtypes were type 16(2.09%),type 58(1.82%),and type 52(1.61%).The positive rate of TCT was 5.69%,including ASC-US(3.91%),LSIL(1.21%),ASC-H(0.32%),HSIL and above(0.23%),and glandular epithelial lesions(0.02%).The age group with the highest incidence of HPV was 41-50 years old,and the positive rate was 5.54%.Compared with other age groups,the difference was statistically significant(P<0.05).Conclusion The HPV subtypes have the highest infection rates of 16,52 and 58 and have obvious age characteristics.HPV infection can cause a series of cervical lesions,and the focus should be on people with high-risk HPV infection.
作者 朱军 张振君 ZHU Jun;ZHANG Zhen-jun(Zhejiang Dian Medical Testing Center Co.,Ltd.,Hangzhou 310030,Zhejiang,China)
出处 《医学信息》 2019年第1期139-141,共3页 Medical Information
关键词 宫颈病变 HPV TCT 宫颈癌 Cervical lesions HPV TCT Cervical cancer
  • 相关文献

参考文献6

二级参考文献54

  • 1吴坤河 ,赖日权 ,张佳立 ,张江宇 ,郜红艺 .宫颈癌液基细胞学筛查与组织学检查的对比[J].实用癌症杂志,2005,20(1):99-99. 被引量:10
  • 2毛玲芝,张江宇,林焊,罗喜平,梁驹卿.人乳头状瘤病毒基因亚型与宫颈病变的关系[J].中国基层医药,2005,12(9):1167-1168. 被引量:25
  • 3Syrjanen S, Shabalova IP, Petrovichev N, et al. Human papilloma virus testing and conventional pap smeear cytology as optional screening tools of women at different risks for cervical cancer in the countries of the former soviet uniom [J]. J Low Genit Tract Dis,2002,6: 97- 110. 被引量:1
  • 4J Solomon D, Davey D, Numan R, et al. The 2001 Bethesda bystem; terminology for reporting results of cervical cytology [ J ]. JAMA, 2002, 287(16) : 2114 -2119. 被引量:1
  • 5MahitoTakeda,NoriakiSakuragi,KazuhiraOkamoto,YukiharuTodo,Shin‐IchiroMinobe,EijiNomura,HiroakiNegishi,MamoruOikawa,RitsuYamamoto,SeiichiroFujimoto.Preoperative serum SCC, CA125, and CA19‐9 levels and lymph node status in squamous cell carcinoma of the uterine cervix[J]. Acta Obstetricia et Gynecologica Scandinavica . 2002 (5) 被引量:1
  • 6Dunne Eileen F,Unger Elizabeth R,Sternberg Maya,McQuillan Geraldine,Swan David C,Patel Sonya S,Markowitz Lauri E.Prevalence of HPV infection among females in the United States. JAMA : the journal of the American Medical Association . 2007 被引量:3
  • 7JacquesFerlay,Hai‐RimShin,FreddieBray,DavidForman,ColinMathers,Donald MaxwellParkin.??Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008(J)Int. J. Cancer . 2010 (12) 被引量:7
  • 8WU RF,Dai M,Qiao YL,et al.Human papillomavirus typedistribution in the cervix of Shenzhen City,People’’Republic of China,a population typical of recent Chinese urbanization. International Journal of Cancer . 2007 被引量:1
  • 9John A. Tidy.Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell . 1991 被引量:1
  • 10Clifford G M,Smith J S,Aguado T,Franceschi S.Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. British Journal of Cancer . 2003 被引量:1

共引文献32

投稿分析
职称考试

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈