Objective:To evaluate the influence of body mass index(BMI)on the long-term prognosis of liver cancer patients after hepatectomy.Methods:Totally,596patients were enrolled with388hepatocellular carcinoma(HCC)cases and208intrahepatic cholangiocellular carcinoma(ICC)cases.Patients were divided into three groups according to the BMI:underweight group(BMI<18.5kg/m^2),normal group(18.5kg/m^2≤BMI<25kg/m^2),and overweight/obesity group(BMI≥25kg/m^2).Patients’clinical features and follow-up data were collected.Kaplan-Meier curve was applied for survival analysis,and Cox regression model was used for univariate and multivariate analysis.Results:In both HCC and ICC cases,the overall survival rate(OS)was significantly lower in the underweight group than that in the other two groups(P<0.05).In HCC cases,the cumulative recurrence rate(CRR)was higher in the underweight group(P<0.001).In ICC cases,there was no statistical difference in CRR among the three groups,but showed similar trend with HCC patients.The OS and CRR had no statistical difference between the normal and overweight/obesity groups.The multivariate analysis indicated that BMI<18.5kg/m^2was an independent prognostic factor for OS and CRR in HCC patients after surgery(P<0.05).Conclusions:Underweight patients had worse OS and higher CRR,whereas overweight and obesity might not affect the post-operative prognosis of liver cancer patients after hepatectomy.Simply using BMI has its limitation as a factor of nutrition status to evaluate the prognosis of liver cancer patients after hepatectomy.
Chinese Journal Of Clinical Medicine
body mass index
overall survival rate
cumulative recurrence rate
张欣,博士,住院医师. E-mail:email@example.com;通信作者:周俭. Tel:021-64037181; E-mail:firstname.lastname@example.org