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24例血清学筛查阴性核酸检测阳性献血者乙型肝炎病毒感染特征分析

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摘要 目的探讨漯河地区无偿献血人群血清学筛查阴性核酸检测阳性献血者乙型肝炎病毒感染的特征。方法选取2016年1月—2017年4月漯河市中心血站采集的32 855例献血者血液标本为研究对象,采用速率法检测ALT,两种不同试剂酶联免疫吸附试验进行初检、复检HBs Ag、抗-HIV、抗-HCV及抗-TP,对血清学检测合格的献血者进行核酸筛查,并对核酸检测结果进行分析。结果在血清学检测合格的32 181例献血者中,检出HBV-DNA阳性24例(0.07%),未检测出HCV-RNA和HIV-RNA阳性献血者;男性和女性HBV-DNA阳性率比较差异无统计学意义(P〉0.05);初次献血与重复献血HBV-DNA阳性率比较,差异有统计学意义(P〈0.05);不同年龄段献血者HBV-DNA阳性率比较,差异有统计学意义(P〈0.05)。18-22岁年龄段献血者HBV-DNA阳性检出率最低,49岁以上年龄段献血者检出率最高;24例HBV-DNA阳性献血者在其献血后第6个月末成功随访21例,窗口期感染1例,隐匿性HBV感染20例。结论血清学筛查合格献血者血液标本存在一定程度的HBV漏检,NAT检测可降低经输血传播HBV的风险,隐匿性感染是本地区HBs Ag阴性HBV-DNA阳性献血者的主要感染形式,为输血传播感染性疾病的主要原因。
作者 冯岩
出处 《社区医学杂志》 2018年第12期90-92,共3页 journal of community medicine
作者简介 冯岩(1967-),女,主管技师,主要从事临床输血与检验工作。
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