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神经烯醇化酶与中枢神经系统发育、损伤修复的研究进展 被引量:1

Research progress of neuron specific enolase in development,injury and repair of the central nervous system
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摘要 神经烯醇化酶(NSE)作为神经元发育、重塑的特异性标志物,在中枢神经系统发育和损伤修复过程中呈时空性表达分布。损伤后NSE的改变可以反映病理变化,通过调节NSE水平可以达到损伤后的修复效果,对神经系统的损伤修复有重要意义。本文中我们就NSE的分子结构、表达调控、生物学功能及其与中枢神经系统发育、损伤修复关系进行综述。 As a specific marker of neuron development and reconstruction, neuron specific enolase (NSE) expresses the spatiotemporal distribution in the development and repair of central nervous system. The change of NSE after central nervous system injury can reflect the pathological changes, and can adjust the level of NSE to achieve the effect of post injury repair. It is important for the repair and damage of the nervous system. In this review, we review the molecular structure, expression regulation, biological function of NSE and its relationship with the development, injury and repair of the central nervous system.
作者 周静莹 张宋欧 孟晓芳 刘学红 ZHOU Jing-ying, ZHANG Song-ou, MENG Xiao-fang, LIU Xue-hong (Histology and Embryology Department, Medical College of Shaoxing University, Zhejiang Shaoxing 312000, China)
出处 《解剖学报》 CSCD 北大核心 2018年第3期395-399,共5页 Acta Anatomica Sinica
基金 浙江省自然科学基金(LY15H170001) 绍兴市公益性技术应用研究计划(2015B70040) 国家级大学生创新创业训练计划(201610349007)
关键词 中枢神经系统 神经烯醇化酶 发育 损伤 修复 Central nervous system Neuron specific enolase Development Injury Repair
作者简介 周静莹(1996-),女(汉族),浙江省宁波市人,在读本科生。;通讯作者(To whom correspondence should be addressed)E—mail:liuxueh6588@126.comTel:(0575)88345877
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