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雌激素受体β在子宫内膜异位症中的作用及意义 被引量:4

The role and significance of estrogen receptor beta in endometriosis
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摘要 子宫内膜异位症(EMs)是妇科常见病、疑难病。雌激素在EMs的发生和发展过程中起着十分重要的作用,并通过经典的雌激素受体ERa和ERβ介导的基因或非基因传导通路发挥生物学效应。通过促进炎性反应,减少凋亡,增加异位内膜的黏附、侵袭及血管生成能力,使得子宫内膜异位症具有类似恶性肿瘤的远处转移和种植生长能力,促进了子宫内膜异位症的发生、发展。 Endometriosis (EMs) is a common and difficult disease in gynecology. Estrogen plays an important role in the occurrence and development of EMs, and plays a biological role through the classical estrogen receptor ERa or ER beta mediated gene or non-gene transduction pathway. By promoting inflammatory response, reducing apoptosis and increasing the adhesion, invasion and angiogenesis ability of ectopic endometrium, endometriosis has similar distant metastasis and growth ability of malignant tumor, and promotes the occurrence and development of endometriosis.
作者 赵红伟 张宗峰 ZHAO Hongwei, ZHANG Zongfeng.( Department of Gyzurecology and Obstetrics, Second Affiliated Hospital of Harbin Medical University,Harbin 150000, China)
出处 《疑难病杂志》 CAS 2018年第3期315-318,共4页 Journal of Difficult and Complicated Cases
关键词 子宫内膜异位症 雌激素 雌激素受体 炎性反应 凋亡 Endometriosis Estrogen Estrogen receptor Inflammation Apoptosis
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