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外排体促进骨再生的研究进展 预览

Research progress on exosomes in promoting bone regeneration
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摘要 外排体是来源于内吞作用的一种小囊泡,在骨再生治疗领域成为一种新的选择。这种小囊泡在细胞间传递物质(如蛋白质、RNA等),从而调节靶细胞的分化、增殖功能等。外排体通过直接调节间充质干细胞的成骨分化、刺激成骨细胞的增殖和活性、调节破骨细胞的成熟和活性以及增加血管生成能力来促进骨再生。同时还能避免生物治疗所带来的细胞毒性和免疫抑制问题。此外外排体疗法的并发症(如肿瘤、血栓形成等)相对于生物治疗来说更少。 Exosomes,small vesicles of endocytic origin,have attracted attention in bone regeneration field. The vesicles travel between cells and deliver functional cargoes like proteins and RNAs,thereby regulating targeted cells differentiation,commitment,function,and proliferation. Exosomes directly regulate MSCs into the osteoblastic lineage,stimulate bone regeneration by directly regulating osteoblast proliferation and activity,regulate osteoclast maturation and activity and stimulate bone growth and regeneration by increasing vessel formation.Meantime,exosomes resolves toxicity and immunogenicity problems caused by biomaterial treatment.Furthermore,compared with living cell transplantation,exosomes present a lower risk for severe complication( such as tumors,emboli formation).
作者 陈文杰 殷嫦嫦 虞蕾琳 李忠友 殷明 CHEN Wen-jie1,2, YIN Chang-chang3, YU Lei-lin4, LI Zhong-you1,2, YIN Ming2 ( 1. Medicine School of Graduate Center, Nanchang University, Nanchang 330006; 2. Dept. of Orthopedics, the Second Hospital Affieiated of Nanchang University, Nanehang 330006;3. Jiujiang Key Laboratory of Translational Medicine, Basic Medical College Jiujiang University, Jiujiang 332000;4. Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang 332000, China)
出处 《基础医学与临床》 CSCD 2018年第2期251-254,共4页 Basic Medical Sciences and Clinics
基金 国家自然科学基金(81160226)
关键词 骨再生 外排体 成骨 bone regeneration exosome osteogenesis
作者简介 通信作者(corresponding author):773733413@qq.com
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