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海马神经振荡的产生机制和功能

The mechanism and function of hippocampal neural oscillation
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摘要 神经元集群(neuronal ensemble)的节律性活动往往能诱导产生清晰可见的神经振荡,反映着该群神经元规则化和同步化的活动。通常依据频率可将神经振荡分为delta振荡(0.5~3 Hz)、theta振荡(4~12 Hz)、beta振荡(12~30 Hz)、gamma振荡(30~100 Hz)和尖波涟漪(sharp-wave ripples, SWR)(〉100 Hz的纹波叠加在0.01~3 Hz的尖波上)。这些神经振荡在人和动物的许多脑区中出现,常伴随着感觉、运动、睡眠等行为产生,在认知、学习和记忆巩固过程中发挥着至关重要的作用。本文简要回顾海马脑区神经振荡的研究历程,对其中的最重要的三种神经振荡——theta振荡、gamma振荡和SWR的产生机制、主要功能及各频率神经振荡的相互作用作出概述,并对今后的研究方向作出展望。 Neural oscillation is rhythmic or repetitive neural activity in the central nervous system that is usually generated by oscillatory activity of neuronal ensembles, reflecting regular and synchronized activities within these cell populations. According to several oscillatory bands covering frequencies from approximately 0.5 Hz to 〉100 Hz, neural oscillations are usually classified as delta oscillation (0.5–3 Hz), theta oscillation (4–12 Hz), beta oscillation (12–30 Hz), gamma oscillation (30–100 Hz) and sharp-wave ripples (〉100 Hz ripples superimposed on 0.01–3 Hz sharp waves). Neural oscillation in different frequencies can be detected in different brain regions of human and animal during perception, motion and sleep, and plays an essential role in cognition, learning and memory process. In this review, we summarize recent findings on neural oscillations in hippocampus, as well as the mechanism and function of hippocampal theta oscillation, gamma oscillation and sharp-wave ripples. This review may yield new insights into the functions of neural oscillation in general.
作者 卢凝 邢丹琴 盛涛 陆巍 LU Ning1, XING Dan-Qin2,3, , SHENG Tao3(1Chien-Shiung Wu College, Southeast University, Nanjing 210096, China;2College of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, China;3The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, China)
出处 《生理学报》 CSCD 北大核心 2017年第5期647-656,共10页 Acta Physiologica Sinica
关键词 海马 神经振荡 theta振荡 gamma振荡 尖波涟漪 hippocampus, neural oscillation theta oscillation gamma oscillation sharp-wave ripples
作者简介 Corresponding author. Tel: +86-25-83789987; Fax: +86-25-83789987; E-mail: luwei@seu.edu.cn
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