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PTK7在不同级别结肠腺瘤组织及瘤旁非肿瘤黏膜组织中的表达意义 预览

Expression and Significance of PTK7 in Different Grade of Colonic Adenoma and Non Tumor Mucosa Adjacent to Tumor
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摘要 目的:研究蛋白酪氨酸激酶-7(Protein tyrosine kinase-7,PTK7)在不同级别结肠腺瘤组织及瘤旁非肿瘤黏膜组织中的表达和意义。方法:收集31例结肠腺瘤组织标本,并进行免疫组化染色检测PTK7蛋白的表达,结合患者的临床病理资料进行统计分析。结果:非肿瘤黏膜组织中PTK7检出率为29.6%(8/27),腺瘤组织中为77.4%(24/31)。瘤旁非肿瘤黏膜组织中,高级别上皮内瘤变与低级别上皮内瘤变比较,差异无统计学意义(字2=0.051,P〉0.05)。非肿瘤黏膜组织与腺瘤组织PTK7表达比较,差异均有统计学意义(P〈0.05)。腺瘤组织中,高级别上皮内瘤变与低级别上皮内瘤变比较,差异有统计学意义(P〈0.05)。未发现PTK7表达与性别(P=0.198)或年龄(P=0.198)之间有相关性。结论:PTK7参与结肠腺瘤的发生发展,其阳性表达对结肠肿瘤的早期干预有提示意义,PTK7可作为预测结直肠癌的发生候选生物标志物。 Objective: To investigate the expression and significance of protein tyrosine kinase-7 ( PTK7 ) in different grade eolorectal adenoma and non tumor mucosa adjacent to tumor.Method: 31 cases of adenoma samples and immtmohistochemieal staining was used to detect the expression of PTK7 protein expressions, combined with cilinical pathological data were statistical analyzed.Result: The detection rate of PTK7 was 29.6% ( 8/27 ) in non-tumorous mucosa and adenoma tissues was 77.4% ( 24/31 ) .PTK7 expression in surrounding non-tumorous mueosa between high-grade adenoma and low-grade adenoma was no significant different ( )(2=0.051, P〉0.05 ) . The difference of PTK7 expression between non-tumorous mucosa and adenoma tissues was statistically significant ( P〈0.05 ) .A marked difference of PTK7 expression was also found between high-grade epithelial adenoma and low-grade epithelial adenoma ( P〈0.05 ) .PTK7 expression was not found to be associated with patient's gender ( P=0.198 ) or age ( P=0.198 ) .Conclusion: PTK7 may involved in the occurrence and development of colorectal adenoma, its overexpression may be a clue for early diagnosis of colorectal tumor, PTK7 may be a candidate biomarker to predict colorectal cancer genesis.
作者 张东海 祁晓莉 张轶华 商晓青 刘洪波 ZHANG Dong-hai, QI Xiao-li, ZHANG Yi-hua, et al.(Capital Medical University Daxing Hospital, Beijing 102600, China.)
出处 《中国医学创新》 CAS 2017年第27期116-119,共4页 Medical Innovation of China
基金 北京市大兴区科委资助课题(2013)
关键词 蛋白酪氨酸激酶-7 结肠腺瘤 上皮内瘤变 免疫组织化学 Protein tyrosine kinase-7 Colorectal adenoma Intraepithelial neoplasia Immunohistochemistry
作者简介 通信作者:祁晓莉
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