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TACE联合调强放疗治疗晚期肝癌的疗效观察 预览 被引量:6

TACE combined with IMRT for the treatment of advanced hepatocellular carcinoma: observation of its curative effect
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摘要 目的评价肝动脉化疗栓塞(TACE)联合调强放疗(IMRT)治疗中晚期肝癌的疗效和不良事件。方法人组的59例中晚期肝癌患者分为TACE联合调强组(治疗组n=30例)与TACE组(对照组n=29例),比较两组之间的早期肿瘤反应率,疾病无进展生存期(PFS),中位生存期(mST)和不良事件。结果治疗组的早期肿瘤反应率明显优于对照组(60.0%对34.4%,P=0.043);治疗组和对照组中位PFS(mPFS)分别为260d和195d(P=0.006),mST分别为468d和431d(P=0.195)。治疗组出现2例严重的肝功能损害。经20余天积极护肝治疗后好转。结论TACE联合调强放疗治疗中晚期肝癌可增加肿瘤早期反应率,延长肿瘤PFS,反应可耐受。 Objective To evaluate the curative effect of transcatheter arterial chemoembolization (TACE) combined with intensity modulated radiation therapy (IMRT) in treating advanced hepatocellular carcinoma (HCC), and to discuss the occurrence of adverse events. Methods A total of 59 patients with advanced HCC were enrolled in this study. The patients were randomly divided into TACE plus IMRT group (study group, n=30) and TACE group (control group, n=29). The early tumor response rate, progression free survival (PFS), median survival time (mST), and adverse reactions were analyzed. Results The early tumor response rate in the study group was 60.0%, which was significantly higher than 34.4% in the control group (P=0.043). PFS of the study group was 260 days, which was remarkably higher than 195 days of the control group (P=0.006). The mST was 468 days in the study group, which was 431 days in the control group (P= 0.195). In the study group, 2 patients developed severe liver function damage, which was improved after active liver protection therapy for more than 20 days. Conclusion For the treatment of advanced HCC, TACE combined with IMRT can improve early tumor response rate and prolong PFS time, moreover, its adverse reactions can be well tolerated by patients. (J Intervent Radiol, 2017, 26: 799-802)
作者 陈德连 胡坚超 江会红 徐镇钱 陈明聪 CHEN Delian, HU Jianchao, JIANG Huihong, XU Zhenqian, CHEN Mingcong.(Department of lnternal Oncology, Taizhou Municipal Tumor Hospital, Taizhou, Zhejiang Province 317502, China)
出处 《介入放射学杂志》 CSCD 北大核心 2017年第9期799-802,共4页 Journal of Interventional Radiology
关键词 原发性肝癌 调强放疗 TACE 动脉灌注 化疗栓塞 primary hepatocellular carcinoma intensity modulated radiation therapy transcatheter arterial chemoembolization arterial infusion chemoembolization
作者简介 通信作者:徐镇钱E—mail:110732450@qq.com
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  • 1沈理 ,陈敏华 ,严昆 ,杨薇 ,高文 ,廖盛日 ,杨仁杰 .探讨经皮射频消融联合肝动脉化学栓塞治疗大肝癌的临床应用效果[J].中华超声影像学杂志,2004,13(8):577-580. 被引量:9
  • 2张成平,熊锦华,胡大荣,闻炜,陈力强,任永强.经皮射频毁损和肝动脉栓塞化疗联合治疗中晚期原发性肝癌的疗效观察[J].中国肿瘤临床,2004,31(22):1309-1310. 被引量:6
  • 3唐树尧,解亦斌,姜涛,朴大勋,关英辉,朱安龙.RFA和TACE联合应用对原发性肝癌的疗效分析[J].哈尔滨医科大学学报,2005,39(2):183-184. 被引量:11
  • 4陆再英,钟南山.内科学(第七版)[M].北京:人民卫生出版社,2008.251,778,803. 被引量:36
  • 5[1]Ono Y,Oshimasa T,Ashikaga R,et al.Longterm results of lipidoltran scatheter arterial embolization with cisplatin or doxorubicin for unresectable hepatocellular carcinoma[J].AmJClin Oncd,2000,23 (6):564 被引量:1
  • 6[2]Seong J,Park H C,Hart K H,et al.Local radiotherapy for unresectable hepatocellular carcinoma patients who failed with transcatheter arterial chemeembolization[J].lnt J Radiat Oncol Biol Phys,2000,47(5):1331-1335 被引量:1
  • 7[3]Hee C P,Jinsil S,Kwang H H,et al.Dose-response relationship in local radiotherapy for hepatocellular carcinoma E[J].lnt JRadia Oncol Biol Phys,2002,54(1):150-155 被引量:1
  • 8[4]Hignchi T,Kikuchi M,Okazaki M,et al.Hepatocellular carci-noma after transcatheter hepatic arterial emeembolization.Ahistopatho logic study of 84 resected cases[J].Cancer,1994,73(9):2259-2263 被引量:1
  • 9[5]Ueno K,Miyazono N,lnone H,et al.Transcatheter arterialchemoem bolization therapy using iodized oil for patients with unresectable hepatocellular carcinoma:evaluation of three kinds ofregimens and analysis of prognostic factors[J].Caneer,2000,88(7):1574-1581 被引量:1
  • 10[6]Lo C M,Ngan H,Tso W K,et al.Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocel lular carcinoma[J].Hepatology,2002,35(5):1164-1171 被引量:1

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