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通腑化痰活血法对脑梗死急性期患者白介素-6C反应蛋白、肿瘤坏死因子-α的影响 预览 被引量:6

Effects of Dredging Fu Organs , Dispersing Phlegm and Activating Blood Method on Interleukin-6, C-reactive Protein and Tumor Necrosis Factor-α Levels in Patients with Acute Cerebral Infarction
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摘要 目的:观察通腑化痰活血法对脑梗死急性期患者白介素-6、C反应蛋白、肿瘤坏死因子-α的影响。方法:80例患者随机分为观察组和对照组,每组各40例,对照组予以西医常规治疗,观察组在对照组基础上加用通腑化痰活血方治疗,治疗30 d。观察2组患者的临床疗效和治疗前后NIHSS评分、血清白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平的变化。结果:观察组总有效率为87.5%,明显优于对照组之总有效率65%(P〈0.05)。观察组治疗后NIHSS评分下降程度优于对照组(P〈0.05)。观察组和治疗组治疗后IL-6、CRP、TNF-α水平明显降低(P〈0.05或P〈0.01),但观察组下降程度明显优于对照组(P〈0.05)。结论:通腑化痰活血法治疗脑梗死急性期疗效显著,且能促进患者神经功能恢复,其作用机制可能与降低患者血清炎性因子有关。 Objective:To observe the effects of dredging fu organs,dispersing phlegm and activating blood methods on serum intedeukin-6,C reactive protein,tumor necrosis factor-α in acute cerebral infarction patients.Methods:80 patients were randomly divided into observation group and control group,40 cases in each group,the control group was treated with routine Western Medicine,the observation group were given Prescription of dredging fu organs,dispersing phlegm and activating blood on the basis of the control group,to observe the curative effect of two groups and NIHSS score,serum interleukin-6 (IL-6),C-reactive protein (CRP),tumor necrosis factor alpha (TNF-α levels changes before and after treatment.Results:The total effective rate of the observation group was 87.5%,which was higher than that of the control group (P 〈0.05).The decline degree of NIHSS score of the observation group was better than that of the control group after treatment(P 〈 0.05).The levels of TNF-α,CRP and IL-6 were significantly decreased in the observation group and the control group (P 〈 0.05 or P 〈 0.01),however,the extent of decline in the observation group was significantly better than those of the control group (P 〈 0.05).Conclusion:Dredging fu organs,dispersing phlegm and activating blood method have significant effect on cerebral infarction in acute stage,and could promote the recovery of neurological function,its mechanism may be related to the decreasing of serum inflammatory factors levels.
作者 王彩红 史春和 马民凯 马红建 WANG Caihong, SHI Chunhe, MA Minkai, MA Hongjian (People's Hospital of Tang County, Tang County, Hebei 072350)
出处 《中国中医药科技》 CAS 2017年第3期268-271,共4页 Chinese Journal of Traditional Medical Science and Technology
基金 河北省保定市科学技术研究与发展指导计划项目(15ZF023)
关键词 脑梗死 急性期 白介素-6 C反应蛋白 肿瘤坏死因子-α 通腑化痰活血法 大承气汤 三化汤 cerebral infarction acute stage C-reactive protein tumor necrosis factor alpha dredging fu organs,dispersing phlegm and activating blood method Da Chengqi Tang Sanhua Tang
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