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心力衰竭患者血清CA125与BNP水平及心功能分析 被引量:1

Correlation between serum CA125 and BNP level and cardiac function in patients with Chronic Heart Failure
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摘要 目的研究并分析慢性心力衰竭患者外周血清糖类抗原CA125水平与心力衰竭定量标志物-脑利钠肽(BNP)水平及心功能的相关性。方法根据NYHA心功能分级标准将100例慢性心力衰竭患者分为Ⅰ-Ⅱ级组、Ⅲ组级、Ⅳ级组3组,比较各组间CA125水平、BNP水平、左室射血分数(LVEF),并分析CA125水平与BNP水平、左室射血分数(LVEF)、左室舒末内径(LVEDD)、左心房内径(LA)的相关性。结果(1)各组间CA125水平、BNP水平、LVEF比较结果如下:Ⅲ级组CA125水平、BNP水平、LVEF均显著高于Ⅰ-Ⅱ级组;Ⅳ级组CA125水平、BNP水平、LVEF均显著高于Ⅰ-Ⅱ级组;Ⅳ级组CA125水平、BNP水平、LVEF均显著高于Ⅲ级组,差异均有统计学意义(P〈0.05)。(2)CA125水平与BNP水平、LVEDD、LA呈正相关性,与LVEF呈负相关性。结论糖类抗原CA125与慢性心力衰竭的严重程度有关,可作为判断和评价慢性心力衰竭的又一有价值的指标,但仍需进一步研究,以便在临床上推广应用。 Objective To study and analyze the correlation between peripheral blood serum carbohydrate antigen CA125 level in patients with chronic heart failure (CHF) and the quantitative markers-brain natriuretie peptide (BNP) and cardiac function in patients with congestive heart failure (CHF). Methods Accord- ing to the NYHA cardiac function grading criteria, 100 cases of chronic heart failure patients were divided into group Ⅰ-Ⅱ, group Ⅲ, group IV in 3 groups. The levels of CA125, BNP and left ventricular ejection fraction (LVEF) were compared between groups, and the correlation between CA125 level and BNP level, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) and left atrial diam ter (LA) was analyzed. Results (1) The following CA125 level, BNP level, LVEF comparison results between groups: The levels of CA125, BNP and LVEF were significantly higher in group Ⅲ than those in group Ⅰ-Ⅱ; The levels of CA125, BNP and LVEF were significantly higher in group IV than those in group Ⅰ-Ⅱ; The levels of CA125, BNP and LVEF were significantly higher in group IV than those in group III, The differences were statistically significant (P〈0.05). (2) The level of CA125 was positively correlated with BNP, LVEDD and LA, and negatively correlated with LVEF. Conclusion Carbohydrate antigen CA125 is associated with the severity of chronic heart failure, and can be used as a valuable index for judging and e- valuating chronic heart failure. But it still needs further study for clinical application.
作者 林毅 LIN Yi (Department of General Medicine, Wuqing People's Hospital, Tianjin 301700, China)
出处 《中国城乡企业卫生》 2017年第6期5-7,共3页 Chinese Journal Urban and Rural Industrial Hygiene
关键词 慢性心力衰竭 糖类抗原CA125 脑利钠肽 左室射血分数 左室舒末内径 左心房内径 Chronic heart failure Carbohydrate antigen CA 125 Brain natriuretic peptide Left ventricular ejection fraction Left ventricular end diastolic diameter Left atrial diameter
作者简介 林毅,本科,副主任医师,研究方向:心血管内科通讯作者:林毅,E-mail:linyi66891@sina.com
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