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HLA—B27对中国人群强直性脊柱炎诊断价值的Meta分析 被引量:2

Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis
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摘要 目的探讨HLA—B27对中国人群强直性脊柱炎(AS)的诊断价值。方法计算机检索PubMed、EMbase、The Cochrane Library(2015年8期)、CNKI以及WanFangData数据库,搜集国内外发表的关于HLA—B27诊断中国人群As的诊断性试验,检索时限均从建库至2015年8月。由2位研究者独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Stata12.0软件进行统计分析。结果共纳入16个研究,共计3137例AS患者,5617例疑似AS患者。Meta分析结果显示,HLA—B27诊断AS的Sen合并=0.91[95%CI(0.89,0.93)]、Spe合并=0.94[95%CI(0.91,0.96)]、+LR合并=14.90195%CI(9.60,23.10)]、-LR合井=0.09[95%CI(0.08,0.12)]、DOR合并=157[95%CI(90,275)]、AUC=0.95[95%CI(0.93,0.97)]。结论HLA—B27检测对中国人群AS诊断价值较高。基于现有研究的缺陷,本研究结论尚需开展更多长期随访的前瞻性研究予以证实。 Objective To explore the diagnostic value of HLA-B27 for ankylosing spondylitis (AS) in Chinese population. Methods We searched PubMed, EMbase, The Cochrane Library (Issue 8, 2015), CNKI, and WanFang data from inception to August 2015, to collect diagnostic studies about HLA-B27 for AS in Chinese population. Two reviewers independently screened literature, extracted data, and assessed the methodological quality of included studies. Then meta- analysis was performed by using Statal2.0 software. Results A total of 16 studies involving 3 137 AS and 5 617 suspect patients were finally included. The results ofmeta-analysis showed that the pooled Sen, Spe, +LR, -LR and DOR were 0.91 (95%CI 0.89 to 0.93), 0.94 (95%CI 0.91 to 0.96), 14.90 (95%CI 9.60 to 23.10), 0.09 (95%CI 0.08 to 0.12) and 157.00 (95%CI 90.00 to 275.00), respectively. The AUC of SROC was 0.98 (95%CI 0.93 to 0.97). Conclusions HLA-B27 detection is of great diagnostic value for AS in Chinese population. However, due to the limited quality and quantity of the included studies, more long-term follow-up prospective studies are needed to verify the above conclusion.
作者 艾金伟 刘盈 关向飞 陈琼 张卫 邓进 裴斌 AI Jin-wei, LIU Ying, GUAN Xiang-fei, CHEN Qiong, ZHANG Wei, DENG Jin, PEI Bin( 1. Evidence-based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China; 2. Department of Micro-orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China)
出处 《中国循证医学杂志》 CSCD 2016年第7期802-808,共7页 Chinese Journal of Evidence-based Medicine
关键词 HLA—B27 强直性脊柱炎 诊断性试验 中国人 META分析 HLA-B27 Ankylosing spondylitis Diagnostic test Chinese population Meta-analysis
作者简介 艾金伟,男(1984年-),硕士,医师,以循证医学、显微外科为主要研究方向,Email:aquai@163.com 刘盈,女(1972年-),硕士,副主任护师,以循证医学、骨科护理学由主要研究方向。Email:abcx-yxzyxzx@163.com 通讯作者,Email:xyxzyxzx@163.com
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