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网络药理学研究中的网络分析技术 预览 被引量:12

Techniques of molecular network analysis in study on network pharmacology
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摘要 网络分析技术是网络药理学研究中的核心技术,通过整合多种学科理论技术对网络药理学研究中相关的分子网络进行多角度多层次的信息挖掘,以准确、客观地查询出能够产生特定药理作用的成分或成分组合、药物或药物组合,以及具有特定生理功能的关键节点、模块等,从而为新药研发、药物作用机制揭示、疾病机制阐释、生物标志物指明等提供有指导价值的信息,尤其对于以阿尔茨海默病为代表的复杂性疾病研究意义更加突出。本文对近年来网络药理学研究中常用的网络分析技术进行了综述。 The technology of network analysis,based on a variety of disciplines theory,is the core technology in the research of network pharmacology,through which we can mine specified information from molecular networks from multi-angle and multi-level. It has been used to investigate and obtain valuable information about the ingredients/drugs with specific pharmacological effects ,the key nodes,modules and motifs with specific biological function,and physiological mechanism of drug action,pathogenesis of dis?ease,or biomarker of disease,especially for the complex disease represented by Alzheimer′s disease(AD). In this paper,the general techniques of network analysis in network pharmacology study are reviewed.
作者 周文霞 王同兴 程肖蕊 韩露 张永祥 ZHOU Wen-xia, WANG Tong-xing, CHENG Xiao-rui, HAN Lu, ZHANG Yong-xiang (State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China)
出处 《国际药学研究杂志》 CAS CSCD 北大核心 2016年第3期399-409,共11页 Foreign Medical Sciences(Section of Pharmarcy)
基金 国家“重大新药创制”科技重大专项资助项目(2012ZX09301003.002.001) 国家科技支撑计划资助项目(2012BA129807)
关键词 网络药理学 阿尔茨海默病 网络节点中心性分析 网络模块分析 网络全局拓扑属性分析 网络对比和相似性分析 网络动态分析 network pharmacology Alzheimer′s disease network centrality analysis network module analysis network global topological properties analysis network comparison and similarity analysis network dynamic analysis
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