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清脑益元汤治疗缺血性中风临床疗效及对NSE、S100B表达的影响

Effects of Qingnao Yiyuan Decoction on NSE and S100B in treating ischemic stroke
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摘要 目的:观察清脑益元汤对缺血性中风急性期的治疗效果,探讨其对血清NSE、S100B表达的影响。方法:采取随机原则,选取广西中医药大学第一附属医院脑病科从2016年4月至12月住院患者60例,随机分为两组:对照组(30例)予以单纯西医常规治疗,治疗组(30例)在对照组基础上加用清脑益元汤。采用酶联免疫吸附法(ELISA)检测两组治疗前及治疗后第3、7、14天血清NSE、S100B表达水平,评估两组患者神经功能缺损程度(NIHSS评分)、中医证候积分、生活能力状态及临床疗效。结果:治疗后,两组患者NIHSS评分、中医临床证候积分及血清NSE、S100B表达水平比较均较前下降,且治疗组下降更明显(P<0.05,P<0.01);生活能力状态较治疗前得到显著改善(P<0.01),且治疗组改善更显著(P<0.05);治疗组临床总有效率(90.0%)显著高于对照组(76.7%)(P<0.05)。结论:清脑益元汤能明显减轻缺血性中风患者急性期神经功能缺损程度,提高临床疗效,其机制可能与下调血清NSE、S100B表达水平有关。 Objective: To observe the effects of Qingnao Yiyuan Decotion in treating acute ischemic stroke, and the influence on serum neuronal specific enolase(NSE) and S100 calcium-binding protein B(S100 B). Methods: A total of 60 hospitalized patients from Department of Encephalopathy in The First Affiliated Hospital of Guangxi University of Chinese Medicine during April 2016 to December 2016 were randomly divided into treatment group and control group, 30 cases in each group. Control group was given western routine therapy, while treatment group was given Qingnao Yiyuan Decoction on the basis of western routine therapy. Enzyme linked immunosorbent assay(ELISA) was used to detect the serum levels of NSE and S100 B of two groups before treatment and 3 days, 7 days, 14 days after treatment, respectively, NIHSS score, TCM syndrome integral, the capability state of life, and the clinical curative effect were evaluated. Results: After treatment, NIHSS score, Chinese clinical syndrome integral, and serum level of NSE and S100 B in the treatment group and control group decreased, and the treatment group decreased more significantly(P<0.05, P<0.01). The capability state of life improved significantly in both groups(P<0.01), the treatment group improved more significantly(P<0.05). Clinical total effective rate in treatment group was significantly higher than that in the control group, clinical total effective rate of two groups were 90.0% and 76.7%, respectively, the difference was statistically significant(P<0.05). Conclusion: Qingnao Yiyuan Decoction can reduce the degree of neurologic impairment of ischemic stroke patients and improve clinical efficacy, the mechanism of which is related to down-regulating serum NSE and S100 B levels.
作者 祝美珍 罗刘军 武丽 岑妍慧 彭岳 陈炜 贾微 肖艳芬 ZHU Mei-zhen;LUO Liu-jun;WU Li;CEN Yan-hui;PENG Yue;CHEN Wei;JIA Wei;XIAO Yan-fen(Guangxi University of Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2019年第2期854-857,共4页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 国家自然科学基金项目(No.81460725) 广西特色实验动物病证模型重点实验室项目(No.J14049) 广西高校科学技术研究重点项目(No.ZD2014069).
关键词 清脑益元汤 缺血性中风 神经元特异性烯醇化酶 S100B钙结合蛋白 神经功能缺损评分 临床疗效 机制 Qingnao Yiyuan Decoction Ischemic stroke Neuronal specific enolase(NSE) S100 calcium-binding protein B(S100B) National Institute of Health Stroke Scale(NIHSS) Clinical effect Mechanism
作者简介 通讯作者:祝美珍,广西壮族自治区南宁市明秀东路179号广西中医药大学,邮编:530001,电话:0771-3937912,E-mail:beauty0822@126.com。
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