Objective To observe the clinical efficacy and safety of Liangxue Tongyu Decoction （凉血通瘀方） in the treatment of chronic daily headache. Methods Eighty cases of chronic daily headache patients were randomly divided into treatment group and control group, with 40 cases in each group. The treatment group was given Liangxue Tongyu Decoction, 1 dose daily ; the control group was given pregabalin tablets orally, 75 mg each time, twice a day. Both groups were treated for 60 days, and the clinical efficacy were compared. The headache attack frequency, head- ache duration, pain degree and the accompanied anxiety and depression were observed before treatment, the 30th day and the 60th day of the treatment. Results The headache attack frequency, duration time and pain degree of the patients in two groups were significantly decreased at the 30th day and the 60th day of treatment compared with those before treatment （P 〈 0. 01 ）. The headache attack frequency and duration time of headache in treatment group at the 30th day of treatment were significantly decreased compared with control group （P 〈0. 01 ）. The improvement of anxiety state at the 60th day of the treatment in the control group was better than that in the treatment group （P 〈 0. 01 ）. The clinical control rate （25%） and total effective rate （97.50%） in the treatment group were higher than those in the control group （5% and 92.50% respectively, P 〈 0.01）. In the control group, there were 8 cases of adverse reactions, the treatment group had no obvious adverse reactions. Conclusion Liangxue Tongyu Decotion seems to have definite curative effect and good security in the treatment of chronic daily headache.
Journal of Traditional Chinese Medicine
chronic daily headache
blood stasis and heat resistance
Liangxue Tongyu Decotion