Objective To study the change of eutopic endometrium in patients with endometriosis, in order to confirm the clinical efficacy of treatment. Methods Forty patients diagnosed as endometriosis by laparoscopy and pathology from November 2013 to May 2014 in the Department of Gynaecology in our hospital were enrolled as endometriosis group. Thirty-eight patients of endometriosis cured in our hospital without recurrence after treatment were selected as cured group. Thirty healthy women were selected as control group. The expression levels of matrix metalloproteinase 9（MMP-9） and vascular endothelial growth factor（VEGF） in the three groups were detected and compared. Results MMP-9 and VEGF expression in endometriosis group were significantly higher than cured group and control group（P〈0.05）, with no statistically significant difference between cured group and control group（P〈0.05）.The expressions of MMP-9 and VEGF were positively correlated（r=0.805, P〈0.05）. Conclusion MMP-9 and VEGF of eutopic endometrium in patients with endometriosis are expressed abnormally, which promote endometriotic lesions.Complete surgical excision of endometriotic lesions combined with drug treatment can postpone recurrence.
Hainan Medical Journal
Matrix metalloproteinase 9（MMP-9）
Vascular endothelial growth factor（VEGF）