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多孔钽颗粒在下颌骨缺损修复中的作用 被引量:7

Effect of porous tantalum pellets on repairing jaw bone defect
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摘要 目的评价多孔钽颗粒对下颌骨骨缺损的修复效果。方法首先拔出比格犬双侧下颌前磨牙,待拔牙创愈合后(3个月)采用牙科种植机在下颌骨缺牙区构建颌骨骨缺损模型,随即将多孔钽颗粒(实验组,n=9)和Bio-oss骨粉(对照组,n=9)分别植入右侧和左侧下颌骨骨缺损区内。半流食喂养3个月后,双侧下颌骨行X线摄片比较2组材料修复骨缺损的能力,然后采用EXAKT切磨机制取硬组织切片,行甲苯胺蓝染色后于显微镜下观察新骨成熟情况。结果 3个月后,大体标本和X线摄片发现:实验组和对照组颌骨骨缺损区内均有新骨生成;按照X线评分标准对骨形成及塑形情况进行评价发现:实验组评分高于对照组[(9.54±0.10)vs(8.98±0.09),P〈0.05],差异有统计学意义。硬组织切片染色观察发现:实验组缺损区骨组织较对照组更为成熟,且包绕了大量的多孔钽颗粒,其相互交联呈网状;虽然对照组(Bio-oss骨粉颗粒)周围有较成熟的骨组织包绕,但颗粒之间仍有大量骨陷窝存在。结论实验结果显示多孔钽颗粒具有良好的诱导成骨能力,其修复颌骨缺损效果优于临床常用的Bio-oss骨粉。 Objective To evaluate the effect of porous tantalum pellets on repairing jaw bone defect.Methods The mandibular premolars of 3 beagle dogs were pulled out. After 3 months,a dental planter was used to construct a bone defect model. Immediately,porous tantalum pellets( experimental group,n = 9) or Bio-oss bone( control group,n = 9) were transplanted into the right and left defect areas. After 3 months,X-ray filming was used to elucidate bone formation and bone modeling. Moreover,the bones were cut into slices with an EXAKT slicer,and toluidine blue staining was used to observe bone maturity. Results After3-month transplantation,the gross specimen and X-ray imaging demonstrated that new bones were found in both the control group and the experiment group,but the bone modeling was significantly higher in the experiment group than in the control group( 9. 54 ± 0. 10 vs 8. 98 ± 0. 09,P 〈 0. 05). Toluidine blue staining demonstrated that bone was more mature in the experiment group,and was inserted into the porous tantalum pellets. However,many bone sags were observed at the periphery of Bio-oss bone in the control group. Conclusion Porous tantalum pellets can better induce bone formation and repair the jaw bone defect than Bio-oss bone.
作者 钟建鑫 节云峰 罗金英 张倩 朱璨 汪昆 王晓亮 周继祥 Zhong Jianxin,Jie Yunfeng,Luo Jinying,Zhang Qian,Zhu Can,Wang Kun,Wang Xiaoliang,Zhou Jixiang(1 Department of Stomatology, Southwest Hospital, Third Military Medical University, Chongqing, 400038 ; 2 Chongqing Runze Pharmaceutical Co. Ltd. , Chongqing, 401120 ; 3 Sichuan Institute for Food and Drug Control, Chengdu, Sichuan Province, 611731, China)
出处 《第三军医大学学报》 CAS CSCD 北大核心 2015年第12期1277-1280,共4页 Acta Academiae Medicinae Militaris Tertiae
关键词 多孔钽颗粒 BIO-OSS骨粉 颌骨缺损 修复效果 porous tantalum pellets Bio-oss bone jaw bone defect repairing effect
作者简介 [通信作者]周继祥,电话:(023)68754387,E—mail:Zhoujx6518@sina.com
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参考文献18

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