硫酸镁在妊娠高血压治疗中的作用预览被引量：47

Effect of magnesium sulfate on patient with pregnancy induced hypertension

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摘要目的研究硫酸镁在治疗妊娠高血压（PIH）中的效果及妊娠高血压时血浆和红细胞内钙、镁离子的浓度变化及其相互关系。方法选取120例妊娠高血压患者和40例健康孕妇,在妊娠后期观察给予硫酸镁治疗前后血浆和红细胞中钙离子和镁离子浓度水平的变化。结果发现血浆中总的钙、镁离子水平在中、重度妊高症组中较正常妊娠组显著降低（P〈0.05）;而红细胞内钙、镁离子水平在中、重度妊高症组中明显高于正常妊娠组（P〈0.05）。而经硫酸镁治疗后,中、重度妊高症患者血浆和红细胞内钙、镁离子的浓度接近正常水平,血压也得到了良好控制。结论镁缺乏是妊高症患者钙镁干扰血压的病理生理基础,予以硫酸镁治疗可有效改善妊高症情况。 Objective To study the therapeutic effect of magnesium sulfate（MgSO4）on patients with pregnancy induced hypertension（PIH）and discover the relationship between the PIH and the concentration changes of calcium and magnesium in plasma and erythrocytes.Methods The calcium and magnesium levels in plasma and erythrocytes of 120 patients with PIH and 30 healthy gravid in their late pregnancy were determined.Meanwhile,after MgSO4 infusion,the changes in plasma and erythrocytes were also analyzed.Results Plasma calcium significantly decreased in patients with moderate and severe PIH.Calcium markedly increased and magnesium noticeably decreased in erythrocytes.After MgSO4 infusion in severe PIH patients,magnesium levels both in plasma and in erythrocytes were largely increased,while calcium significantly increased in plasma and decreased in erythrocytes to normal levels nearly.Conclusion These results indicate that magnesium deficiency is the basis of calcium and magnesium disturbances in PIH,and MgSO4 treatment may effectively improve these situations.

作者高蓉范春元张朝晖 GAO Rong, FAN Chun-yuan, ZHANG Zhao-hui （1. Dujiangyan Medical Center, Chengdu 611830; 2. College of Sichuan Radio and TV University, Chengdu 610000）

机构地区都江堰市医疗中心四川省广播电视大学直属学院

出处《西部医学》 2015年第3期389-391,共3页 Medical Journal of West China

基金四川省科技厅支撑计划资助项目（10ZC1820）

关键词妊娠高血压钙离子镁离子硫酸镁 Pregnancy induced hypertension Magnesium Calcium Magnesium sulfate

分类号 R714.246 [医药卫生—妇产科学][医药卫生—临床医学]

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